Transferrin Protein (TF) (AA 20-697) (Fc Tag)

N° du produit ABIN6253541

Détail du produit

Antigène: Transferrin (TF)

Type de proteíne: Recombinant

Attributs du protein: AA 20-697

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette Transferrin protéine est marqué à la Fc Tag.

Séquence: AA 20-697

Pureté: >95 % as determined by SDS-PAGE.

niveau d'endotoxine: Less than 0.1 EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Tris with Glycine, Arginine and NaCl,  pH 7.5

Conseil sur la manipulation: Please avoid repeated freeze-thaw cycles.

Stock: -20 °C

Détail du antigène

Antigène: Transferrin (TF)

Autre désignation: Transferrin (TF Produits)

Synonymes: ltf Protein, pro1557 Protein, pro2086 Protein, mgc107777 Protein, LOC692564 Protein, TF Protein, LOC100144362 Protein, tf Protein, LTF Protein, TFEW Protein, conalbumin Protein, tf-b Protein, MGC64306 Protein, PRO1557 Protein, PRO2086 Protein, TFQTL1 Protein, AI266983 Protein, Cd176 Protein, HP Protein, Tf Protein, Tfn Protein, hpx Protein, Trf Protein, cb285 Protein, gavi Protein, id:ibd3238 Protein, id:ibd3525 Protein, sb:cb285 Protein, wu:fb57g06 Protein, wu:fb62h02 Protein, wu:fb63h10 Protein, wu:fb64h10 Protein, zgc:112154 Protein, 143958_at Protein, CG6186 Protein, Dmel\\CG6186 Protein, TSF1 Protein, anon-EST:Posey265 Protein, tsf1 Protein, Pro-TRH Protein, IL-5 Protein, STF I Protein, TRF1 Protein, sTF1 Protein, sTf Protein, tf1 Protein, transferrin Protein, serotransferrin Protein, transferrin (ovotransferrin) Protein, transferrin L homeolog Protein, melanotransferrin Protein, transferrin-a Protein, Transferrin 1 Protein, thyrotropin releasing hormone Protein, interleukin 5 Protein, TF Protein, LOC477072 Protein, tf Protein, Tf Protein, LOC100144362 Protein, tf.L Protein, LOC5575625 Protein, Trf Protein, tfa Protein, Tsf1 Protein, TRH Protein, IL5 Protein, LOC101085148 Protein, LOC100726872 Protein, trf Protein

Sujet: Transferrin is also known as Serotransferrin, Beta-1 metal-binding globulin, TF, and is iron-binding blood plasma glycoproteins that control the level of free iron in biological fluids. Although iron bound to transferrin is less than 0.1 % (4 mg) of the total body iron, it is the most important iron pool, with the highest rate of turnover (25 mg/24 h). The affinity of transferrin for Fe(III) is extremely high (1023 M-1 at pH 7.4) but decreases progressively with decreasing pH below neutrality.When not bound to iron, it is known as "apo-transferrin"". In humans, transferrin consists of a polypeptide chain containing 679 amino acids. It is a complex composed of alpha helices and beta sheets to form two domains (the first situated in the N-terminus and the second in the C-terminus). The N- and C- terminal sequences are represented by globular lobes and between the two lobes is an iron-binding site. The liver is the main source of manufacturing transferrin, but other sources such as the brain also produce this molecule . Transferrin is also associated with the innate immune system. Transferrin is found in the mucosa and binds iron, thus creating an environment low in free iron that impedes bacteria survival in a process called iron withholding. The level of transferrin decreases in inflammation. The metal binding properties of transferrin have a great influence on the biochemistry of plutonium in humans. Transferrin has a bacteriocidal effect on bacteria, in that it makes Fe3+ unavailable to the bacteria.Carbohydrate deficient transferrin increases in the blood with heavy ethanol consumption and can be monitored via laboratory testing.

Poids moléculaire: 101.8 kDa

NCBI Accession: NP_598738

Pathways: Transition Metal Ion Homeostasis