CD40 Ligand Protein (CD40LG) (AA 113-261) (Fc Tag)

N° du produit ABIN6253627

Protéine Recombinant CD40 Ligand exprimée dans HEK-293 Cells.

Aperçu rapide pour CD40 Ligand Protein (CD40LG) (AA 113-261) (Fc Tag) (ABIN6253627)

Antigène: CD40 Ligand (CD40LG)

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain, Macaque rhésus

Source: HEK-293 Cells

Pureté: >95 % as determined by SDS-PAGE.

Détail du produit

Attributs du protein: AA 113-261

Purification/Conjugué: Cette CD40 Ligand protéine est marqué à la Fc Tag.

Séquence: AA 113-261

niveau d'endotoxine: Less than 0.1 EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH 7.5

Conseil sur la manipulation: Please avoid repeated freeze-thaw cycles.

Stock: -20 °C

Détail du antigène

Antigène: CD40 Ligand (CD40LG)

Autre désignation: CD40 Ligand

Sujet: CD40 ligand is also known as CD40L, CD154, TNFSF5 and T-cell antigen Gp39, is a single-pass type I I membrane protein which belongs to the TNF superfamily of molecules. CD40 ligand is expressed predominantly on activated CD4+ T lymphocytes, and also found in other types of cells, including platelets, mast cells, macrophages, basophils, NK cells, B lymphocytes, as well as non-haematopoietic cells (smooth muscle cells, endothelial cells, and epithelial cells). Although all monomeric, dimeric and trimeric forms of soluble CD40 ligand can bind to CD40, the trimeric form of soluble CD40 ligand has the most potent biological activity through oligomerization of cell surface CD40, a common feature of TNF receptor family members. CD40 ligand binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In general, CD40 ligand plays the role of a costimulatory molecule and induces activation in APC in association with T cell receptor stimulation by MHC molecules on the APC. In total CD40 ligand has three binding partners: CD40, α5β1 integrin and αIIbβ3. CD40 ligand regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper IgM syndrome.

Poids moléculaire: 43.1 kDa

NCBI Accession: NP_000065

Pathways: Signalisation NF-kappaB, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints