MECOM Protein (AA 1-169) (His tag)

N° du produit ABIN6387329

Détail du produit

Antigène: MECOM (MDS1 and EVI1 Complex Locus (MECOM))

Type de proteíne: Recombinant

Attributs du protein: AA 1-169

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette MECOM protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Séquence: MGSSHHHHHH SSGLVPRGSH MGSMRSKGRA RKLATNNECV YGNYPEIPLE EMPDADGVAS TPSLNIQEPC SPATSSEAFT PKEGSPYKAP IYIPDDIPIP AEFELRESNM PGAGLGIWTK RKIEVGEKFG PYVGEQRSNL KDPSYGWEVH LPRSRRVSVH SWLYLGKRSS DVGIAFSQAD VYMPGLQCAF LS

Pureté: > 85 % by SDS - PAGE

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Denatured

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: Liquid. In 20  mM Tris-HCl buffer (  pH 8.0) containing , 10 % glycerol, 0.4M urea

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: MECOM (MDS1 and EVI1 Complex Locus (MECOM))

Autre désignation: MDS1 (MECOM Produits)

Synonymes: AML1-EVI-1 Protein, EVI1 Protein, MDS1 Protein, MDS1-EVI1 Protein, PRDM3 Protein, D630039M04Rik Protein, Evi-1 Protein, Evi1 Protein, Jbo Protein, Mds Protein, Mds1 Protein, Mds1-Evi1 Protein, Prdm3 Protein, Znfpr1b1 Protein, evi1 Protein, im:7140716 Protein, prdm3 Protein, evi-1 Protein, mecom Protein, mecom-a Protein, mecom-b Protein, xEvi-1 Protein, evi1-B Protein, MDS1 and EVI1 complex locus Protein, MDS1 and EVI1 complex locus L homeolog Protein, MDS1 and EVI1 complex locus S homeolog Protein, MECOM Protein, Mecom Protein, mecom Protein, mecom.L Protein, mecom.S Protein

Sujet: MDS1 is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. Recombinant human MDS1 protein, fused to His-tag at N-terminus, was expressed in E.coli

Poids moléculaire: 21.1kDa (192aa)

NCBI Accession: NP_004982