Superoxide dismutase copper chaperone Protein (AA 1-274) (His tag)

N° du produit ABIN667211

Détail du produit

Antigène: Superoxide dismutase copper chaperone (CCS) (Copper Chaperone For Superoxide Dismutase (CCS))

Type de proteíne: Recombinant

Attributs du protein: AA 1-274

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette Superoxide dismutase copper chaperone protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Attributs du produit: CCS, 1-274aa, Human, His tag, E.coli

Pureté: > 90 % by SDS - PAGE

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/ml (determined by Bradford assay)

Buffer: Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 0.2M NaCl 1mM DTT, 10% glycerol

Stock: 4 °C

Détail du antigène

Antigène: Superoxide dismutase copper chaperone (CCS) (Copper Chaperone For Superoxide Dismutase (CCS))

Autre désignation: CCS (CCS Produits)

Synonymes: ccs Protein, MGC82563 Protein, CCS Protein, DDBDRAFT_0189222 Protein, DDBDRAFT_0238038 Protein, DDB_0189222 Protein, DDB_0238038 Protein, ATCCS Protein, COPPER/ZINC SUPEROXIDE DISMUTASE COPPER CHAPERONE Protein, F5O11.26 Protein, F5O11_26 Protein, copper chaperone for SOD1 Protein, Ccsd Protein, copper chaperone for superoxide dismutase L homeolog Protein, copper chaperone for superoxide dismutase Protein, copper chaperone for SOD1 Protein, ccs.L Protein, ccs Protein, CCS Protein, LOC552629 Protein, Ccs Protein

Sujet: CCS is essential for the incorporation of copper into SOD-1, and therefore is necessary for its enzymatic activity. CCS prevents copper ions from binding to intracellular copper scavengers and provides the SOD-1 enzyme with the necessary copper cofactor. CCS escorts copper only to SOD-1 and fails to deliver copper to proteins in the mitochondria, nucleus or secretory pathway. While many tissues express CCS, the chaperone is most abundant in the kidney, liver and Purkinje cells in the neuropil of the central nervous system. Recombinant human CCS protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: Copper chaperone for superoxide dismutase,. NCBI no.: NP_005116

Poids moléculaire: 31.2 kDa (294aa), confirmed by MALDI-TOF

Pathways: Transition Metal Ion Homeostasis