B-Cell Linker Protein (BLNK) (AA 1-456) (His tag)

N° du produit ABIN667353

Détail du produit

Antigène: B-Cell Linker (BLNK)

Type de proteíne: Recombinant

Attributs du protein: AA 1-456

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette B-Cell Linker protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Attributs du produit: BLNK, 1-456aa, Human, His tag, E.coli

Pureté: > 90 % by SDS - PAGE

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/ml (determined by BCA assay)

Buffer: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 0.1M NaCl, 1mM DTT, 0.1mM PMSF

Stock: 4 °C

Détail du antigène

Antigène: B-Cell Linker (BLNK)

Autre désignation: BLNK (BLNK Produits)

Synonymes: BLNK Protein, blnk Protein, MGC147045 Protein, BASH Protein, Bca Protein, Ly-57 Protein, Ly57 Protein, Lyw-57 Protein, SLP-65 Protein, AGM4 Protein, BLNK-S Protein, LY57 Protein, SLP65 Protein, bca Protein, B-cell linker Protein, B cell linker Protein, BLNK Protein, blnk Protein, Blnk Protein

Sujet: BLNK, also known as B-cell linker, is essential for normal B-cell development. This protein has been shown to associate with the effector proteins GRB2, Vav, NCK and PLC gamma following activation of the B cell receptor. It is phosphorylated by the Syk tyrosine kinase, which in turn permits activation of downstream effector proteins including GRB2 and PLC gamma. Recombinant human BLNK protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. Synonyms: B-cell linker, BASH, BLNK-S, LY57, MGC111051, SLP-65, SLP65. NCBI no.: AAH18906

Poids moléculaire: 52.6 kDa (476aa), confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)

Pathways: BCR Signaling