IGSF11 Protein (AA 23-241) (Fc Tag,AVI tag,Biotin)

N° du produit ABIN6923166

Détail du produit

Antigène: IGSF11 (Immunoglobulin Superfamily, Member 11 (IGSF11))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 23-241

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette IGSF11 protéine est marqué à la Fc Tag,AVI tag,Biotin.

Séquence: AA 23-241

Specificité: Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.

Pureté: >95 % as determined by SDS-PAGE.

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Commentaires:

Ready-to-use AvitagTM biotinylated protein:
The product is exclusively produced using the AvitagTM technology. Briefly, a unique 15 amino acid peptide, the Avi tag, is introduced into the recombinant protein during expression vector construction. The single lysine residue in the Avi tag is enzymatically biotinylated by the E. Coli biotin ligase BirA.

This single-point enzymatic labeling technique brings many advantages for commonly used binding assays. The biotinylation happens on the lysine residue of Avi tag, and therefore does NOT interfere with the target protein's natural binding activities. In addition, when immobilized on an avidin-coated surface, the protein orientation is uniform because the position of the Avi tag in the protein is precisely controlled.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Tris with Glycine, Arginine and NaCl,  pH 7.5

Conseil sur la manipulation: Please avoid repeated freeze-thaw cycles.

Stock: -20 °C

Détail du antigène

Antigène: IGSF11 (Immunoglobulin Superfamily, Member 11 (IGSF11))

Autre désignation: VSIG3 (IGSF11 Produits)

Synonymes: sc:d812 Protein, seurat Protein, BT-IgSF Protein, CT119 Protein, CXADRL1 Protein, Igsf13 Protein, VSIG3 Protein, 1700025L02Rik Protein, immunoglobulin superfamily member 11 Protein, immunoglobulin superfamily member 11 L homeolog Protein, immunoglobulin superfamily, member 11 Protein, IGSF11 Protein, igsf11 Protein, igsf11.L Protein, Igsf11 Protein

Sujet: VSIG3, also known as IGSF11, BT-IgSF, and CLMP, is a homophilic adhesion molecule that preferentially expressed in the brain. The function of VSIG3 is to stimulate cell growth through homophilic interactions. In clinical, the VSIG3 has been reported to as a novel target for cancer immunotherapy of gastrointestinal and hepatocellular carcinomas. In addition, VSIG-3 is also a ligand of B7 family member VISTA/PD-1H and inhibits human T-cell functions through a novel VSIG-3/VISTA pathway. VSIG-3/VISTA co-inhibitory pathway may provide new strategies for the treatment of human cancers and autoimmune disorders.

Poids moléculaire: 51.5 kDa

NCBI Accession: NP_001015887