CCL2 Protein (AA 24-99) (Biotin)

N° du produit ABIN6952161

Cette protéine Recombinant CCL2 est produite dans Escherichia coli (E. coli).

Aperçu rapide pour CCL2 Protein (AA 24-99) (Biotin) (ABIN6952161)

Antigène: CCL2 (Chemokine (C-C Motif) Ligand 2 (CCL2))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: Escherichia coli (E. coli)

Application: Cell Migration Assay (CMA), Flow Cytometry (FACS)

Pureté: > 97 % by SDS PAGE

Détail du produit

Attributs du protein: AA 24-99

Purification/Conjugué: Cette CCL2 protéine est marqué à la Biotin.

Séquence: QPDAINAPVT CCYNFTNRKI SVQRLASYRR ITSSKCPKEA VIFKTIVAKE ICADPKQKWV QDSIDHLDKQ TQTPKT

Attributs du produit: Biotininylated Recombinant Human CCL2 (MCP-1)

niveau d'endotoxine: <0.01 EU per 1μg of the protein by the LAL method

Biological Activity Comment: EC50 = 0.25-1.2 nM determined by Migration Assay of recombinant CCR2 containing cells

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Spin tube prior to resuspending. Recommended at 100 μg/mL in sterile water

Stock: -20 °C,-80 °C

Stockage commentaire: 12 months from date of receipt, -20 to -70 °C as supplied.
Suggest to use immediately after reconstitution
1 month at -20 to -70 °C under sterile conditions after reconstitution.

Date de péremption: 12 months

Détail du antigène

Antigène: CCL2 (Chemokine (C-C Motif) Ligand 2 (CCL2))

Autre désignation: CCL2 (MCP-1)

Sujet: Monocyte chemoattractant protein-1 (MCP-1) (CCL2) is produced by many cell types at sites of inflammation. It regulates chemotaxis and transendothielial migration of monocytes, as well as memory T cells and natural killer cells by interacting with their membrane surface receptor CCR2. MCP-1 has also been implicated in a number of disease states, such as rheumatoid arthritis, psoriasis, atherosclerosis, autoimmune diseases, tumor progression, and HIV infection. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It binds to chemokine receptors CCR2 and CCR4.

Poids moléculaire: 11.085 kDa

UniProt: P13500

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, ER-Nucleus Signaling, Unfolded Protein Response, Phosphorylation & l'infection par le SRAS-CoV-2