IL12A & IL27B (AA 20-189) (Active) protein (His tag)

N° du produit ABIN6992356

Détail du produit

Antigène: IL12A & IL27B

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 20-189

Origine: Humain, Rat

Source: HEK-293 Cells

Purification/Conjugué: His tag

Fonction: Human IL-23 alpha & Rat IL-12 beta Heterodimer Protein, His Tag&Tag Free (MALS verified)

Pureté: >90 % as determined by SDS-PAGE.

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS, pH 7.4

Stock: -20 °C

Détail du antigène

Antigène: IL12A & IL27B

Autre désignation: IL23A & IL12B

Sujet: Interleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Poids moléculaire: 20.6 kDa, 35.9 kDa