Fusion Glycoprotein Protein (F) (AA 27-487) (His tag)

N° du produit ABIN7013074

Détail du produit

Antigène: Fusion Glycoprotein (F)

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 27-487

Origine: Nipah Virus (NiV)

Source: HEK-293 Cells

Purification/Conjugué: Cette Fusion Glycoprotein protéine est marqué à la His tag.

Fonction: Nipah virus Fusion glycoprotein, His Tag

Pureté: >95 % as determined by SDS-PAGE.

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS

Stock: -20 °C

Détail du antigène

Antigène: Fusion Glycoprotein (F)

Autre désignation: Fusion glycoprotein (F Produits)

Classe de substances: Viral Protein

Sujet: Hendra virus (HeV) and Nipah virus (NiV) are henipaviruses discovered in the mid-to late 1990s that possess a broad host tropism and are known to cause severe and often fatal disease in both humans and animals. HeV and NiV infect host cells through the coordinated efforts of two envelope glycoproteins. The G glycoprotein attaches to cell receptors, triggering the fusion (F) glycoprotein to execute membrane fusion. G is a type II homotetrameric transmembrane protein responsible for binding to ephrinB2 or ephrinB3 (ephrinB2/B3) receptors. F is a homotrimeric type I transmembrane protein that is synthesized as a premature F0 precursor and cleaved by cathepsin L during endocytic recycling to yield the mature, disulfide-linked, F1 and F2 subunits. Upon binding to ephrinB2/B3, NiV G undergoes conformational changes leading to F triggering and insertion of the F hydrophobic fusion peptide into the target membrane. Subsequent refolding into the more stable post-fusion F conformation drives merger of the viral and host membranes to form a pore for genome delivery to the cell cytoplasm.

Poids moléculaire: 55.9 kDa

NCBI Accession: NP_112026