TREM2 Protein (AA 19-174) (Fc Tag)

N° du produit ABIN7013683

Détail du produit

Antigène: TREM2 (Triggering Receptor Expressed On Myeloid Cells 2 (TREM2))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 19-174

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette TREM2 protéine est marqué à la Fc Tag.

Séquence: AA 19-174

Attributs du produit: Cynomolgus TREM2 Protein, His Tag

Pureté: >95 % as determined by SDS-PAGE.

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH 7.5

Stock: -20 °C

Détail du antigène

Antigène: TREM2 (Triggering Receptor Expressed On Myeloid Cells 2 (TREM2))

Autre désignation: TREM2 (TREM2 Produits)

Synonymes: TREM-A1 Protein, TREM-B1 Protein, TREM2 Protein, trem-2 Protein, trem2a Protein, trem2b Protein, trem2c Protein, TREM-2 Protein, Trem2a Protein, Trem2b Protein, Trem2c Protein, triggering receptor expressed on myeloid cells 2 Protein, trem-like transcript 2 protein Protein, TREM2 Protein, trem2 Protein, LOC100228399 Protein, Trem2 Protein

Sujet: Triggering receptor expressed on myeloid cells 2 (TREM2) is a cell surface receptor of the immunoglobulin superfamily. The TREM2 is found in various tissue macrophages, such as CNS microglia, bone osteoclasts, alveolar, peritoneal and intestinal macrophages. TREM2 is also present on cultured bone marrow-derived macrophages and monocyte-derived dendritic cells. Some research have identified a rare variant of TREM2 that is a risk factor for Alzheimer disease (AD), which is the most common form of late-onset dementia.The extracellular region of TREM2 contains a single immunoglobulin superfamily domain and binds polyanionic ligands, such as bacterial lipopolysaccharide (LPS) and phospholipids8. Upon ligand binding, TREM2 transmits intracellular signals through an adaptor, DAP12 (also known as TYRO protein tyrosine kinase-binding protein (TYROBP)), which is associated with the transmembrane region of TREM2 and which recruits the protein tyrosine kinase SYK through its cytosolic immunoreceptor tyrosine-based activation motifs (ITAMs). TREM2 is a pro-tumorigenic marker of tumor-infiltrating macrophages in mouse models and human tumors that can be targeted to curb tumor growth and improve the efficacy of checkpoint blockade therapy while remodeling the landscape of tumor-infiltrating macrophages.

Poids moléculaire: 43.9 kDa

NCBI Accession: NP_061838