CD200R1 Protein (AA 27-266) (His tag)
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- Antigène Voir toutes CD200R1 Protéines
- CD200R1 (CD200 Receptor 1 (CD200R1))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
- Attributs du protein
- AA 27-266
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette CD200R1 protéine est marqué à la His tag.
- Attributs du produit
- Human CD200 R1 / CRTR2 Protein, His Tag
- Pureté
- >90 % as determined by SDS-PAGE.
- niveau d'endotoxine
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product CD200R1 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Stock
- -20 °C
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- Antigène
- CD200R1 (CD200 Receptor 1 (CD200R1))
- Autre désignation
- CD200 R1 (CD200R1 Produits)
- Synonymes
- CD200R Protein, HCRTR2 Protein, MOX2R Protein, OX2R Protein, Mox2r Protein, CD200R1 Protein, CD200R2 Protein, CD200R-B1V1 Protein, CD200R1A Protein, CD200 receptor 1 Protein, cell surface glycoprotein CD200 receptor 1 Protein, CD200 receptor 1-like Protein, CD200R1 Protein, Cd200r1 Protein, LOC487977 Protein, CD200R1L Protein
- Sujet
- Cell surface glycoprotein CD200 receptor 1 is a protein that in humans is encoded by the CD200R1 gene. This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. CD200 and its receptor CD200R are both type-1 membrane glycoproteins, which are members of the immunoglobulin superfamily (IgSF). Besides the inhibitory effect on macrophages, CD200/CD200R also play an important role in regulating the regulatory T cells, allergicreaction, autoimmune diseases, allograft, neurological diseases and other autoimmune-related diseases. The interaction between CD200, which is mainly present in neurons but also in astrocytes, and CD200R1, which is mainly present in microglia, is one of the mechanisms involved in keeping the microglial proinflammatory phenotype under control in physiological conditions. Alterations in the expression of CD200 and CD200R1 have been described in neurodegenerative diseases, but little is known about the mechanism of regulation of these proteins under physiological or pathological conditions.
- Poids moléculaire
- 28.7 kDa
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