PHAP1 Protein (GST tag,His tag)

N° du produit ABIN7317458

Détail du produit

Antigène: PHAP1 (ANP32A) (Acidic (Leucine-Rich) Nuclear phosphoprotein 32 Family, Member A (ANP32A))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette PHAP1 protéine est marqué à la GST tag,His tag.

Fonction: Recombinant Human ANP32A/PHAP1 Protein (His & GST Tag)

Séquence: Glu 2-Lys 238

Attributs du produit: A DNA sequence encoding the of human ANP32A (NP_006296.1) (Glu 2-Lys 238) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Pureté: > 85 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 10 % glycerol, 1 mM DTT, 0.5 mM GSH

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: PHAP1 (ANP32A) (Acidic (Leucine-Rich) Nuclear phosphoprotein 32 Family, Member A (ANP32A))

Autre désignation: ANP32A/PHAP1 (ANP32A Produits)

Synonymes: C15orf1 Protein, HPPCn Protein, I1PP2A Protein, LANP Protein, MAPM Protein, PHAP1 Protein, PHAPI Protein, PP32 Protein, Anp32 Protein, W91701 Protein, pp32 Protein, Anp32a Protein, CG5784 Protein, CT18148 Protein, CT42180 Protein, Dmel\\CG5784 Protein, anon-EST:fe3A2 Protein, wu:fj36e08 Protein, zgc:55516 Protein, ANP32D Protein, acidic nuclear phosphoprotein 32 family member A Protein, acidic (leucine-rich) nuclear phosphoprotein 32 family, member A Protein, CG5784 gene product from transcript CG5784-RB Protein, acidic nuclear phosphoprotein 32 family member A L homeolog Protein, ANP32A Protein, Anp32a Protein, Mapmodulin Protein, anp32a Protein, anp32a.L Protein

Sujet:

Background: acidic leucine-rich nuclear phosphoprotein 32 family member A, also known as acidic nuclear phosphoprotein pp32, Leucine-rich acidic nuclear protein, Mapmodulin, Potent heat-stable protein phosphatase 2A inhibitor I1PP2A, Putative HLA-DR-associated protein I, PHAPI and ANP32A, is a nucleus, cytoplasm and endoplasmic reticulum. ANP32A / LANP is expressed in all tissues tested. It is highly expressed in kidney and skeletal muscle, moderate levels of expression is in brain, placenta and pancreas. ANP32A / LANP is weakly expressed in lung. It is found in all regions of the brain examined (amygdala, caudate nucleus, corpus callosum, hippocampus and thalamus), with highest levels in amygdala. ANP32A / LANP is a component of the SET complex, which also contains SET, APEX1, HMGB2 and NME1. It directly interacts with SET. ANP32A / LANP also interacts with ATXN1/SCA1. ANP32A / LANP is implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. ANP32A / LANP plays a role in E4F1-mediated transcriptional repression.

Synonym: C15orf1,HPPCn,I1PP2A,LANP,MAPM,PHAP1,PHAPI,PP32

Poids moléculaire: 55.4 kDa

NCBI Accession: NP_006296