ACVR1 Protein (His tag,Fc Tag)

N° du produit ABIN7194135

Détail du produit

Antigène: ACVR1 (ACRV1) (Activin Receptor Type I (ACRV1))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette ACVR1 protéine est marqué à la His tag,Fc Tag.

Fonction: Recombinant Mouse ALK-2/ACVR1 Protein (His & Fc Tag)(Active)

Séquence: Met 1-Glu 123

Attributs du produit: A DNA sequence encoding the mouse ACVR1 (NP_031420.2) precursor (Met 1-Glu 123) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.

Pureté: > 90 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Measure by its ability to bind with human BMP2 in a functional ELISA.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: ACVR1 (ACRV1) (Activin Receptor Type I (ACRV1))

Autre désignation: ALK-2/ACVR1 (ACRV1 Produits)

Synonymes: ACTRI Protein, ACVR1A Protein, ACVRLK2 Protein, ALK2 Protein, FOP Protein, SKR1 Protein, TSRI Protein, ActR-IA Protein, ActR-I Protein, ActRIA Protein, Acvr Protein, Acvrlk2 Protein, Alk-2 Protein, Alk8 Protein, D330013D15Rik Protein, Tsk7L Protein, actri Protein, acvr1 Protein, acvr1-a Protein, acvr1-b Protein, acvr1a Protein, acvrlk2 Protein, alk-2 Protein, alk2 Protein, alk8 Protein, fop Protein, sax Protein, skr1 Protein, tsri Protein, xALK-2 Protein, activin A receptor type 1 Protein, activin A receptor, type 1 Protein, activin A receptor type 1 S homeolog Protein, ACVR1 Protein, Acvr1 Protein, acvr1.S Protein

Sujet:

Background: ALK-2, also termed as ACVR1, was initially identified as an activin type I receptor because of its ability to bind activin in concert with ActRII or ActRIIB. ALK-2 is also identified as a BMP type I receptor. It has been demonstrated that ALK-2 forms complex with either the BMP-2/7-bound BMPR-II or ACVR2A /ACVR2B. ALK-1 and ALK-2 presenting in the yeast Saccharomyces cerevisiae are two haspin homologues. Both ALK-1 and ALK-2 exhibit a weak auto-kinase activity in vitro, and are phosphoproteins in vivo. ALK-1 and ALK-2 levels peak in mitosis and late-S/G2. Control of protein stability plays a major role in ALK-2 regulation. The half-life of ALK-2 is particularly short in G1. Overexpression of ALK-2, but not of ALK-1, causes a mitotic arrest, which is correlated to the kinase activity of the protein. This suggests a role for ALK-2 in the control of mitosis. Endoglin is phosphorylated on cytosolic domain threonine residues by the TGF-beta type I receptors ALK-2 and ALK-5 in prostate cancer cells. Endoglin did not inhibit cell migration in the presence of constitutively active ALK-2. Defects in ALK-2 are a cause of fibrodysplasia ossificans progressiva (FOP).

Synonym: ActR-I,ActRIA,Acvr,Acvrlk2,Alk-2,ALK2,Alk8,D330013D15Rik,SKR1,Tsk7L

Poids moléculaire: 40 kDa

NCBI Accession: NP_031420