ACBD6 Protein (His tag)

N° du produit ABIN7317652

Détail du produit

Antigène: ACBD6 (Acyl-CoA Binding Domain Containing 6 (ACBD6))

Type de proteíne: Recombinant

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette ACBD6 protéine est marqué à la His tag.

Fonction: Recombinant Human ACBD6 Protein (His Tag)

Séquence: Met 1-Ala 282

Attributs du produit: A DNA sequence encoding the full length of human ACBD6 (NP_115736.1) (Met 1-Ala 282) was expressed, with a polyhistidine tag at the N-terminus.

Pureté: > 96 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 50 mM Tris, 100 mM NaCl, pH 8.0

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: ACBD6 (Acyl-CoA Binding Domain Containing 6 (ACBD6))

Autre désignation: ACBD6 (ACBD6 Produits)

Synonymes: MGC79661 Protein, DDBDRAFT_0188797 Protein, DDBDRAFT_0266382 Protein, DDB_0188797 Protein, DDB_0266382 Protein, ACBP Protein, ACYL-COA-BINDING PROTEIN Protein, F5M6.27 Protein, F5M6_27 Protein, acyl-CoA-binding protein 6 Protein, 0610010G04Rik Protein, 2610100E10Rik Protein, wu:fc18d09 Protein, wu:fc69g03 Protein, LHX4 antisense RNA 1 Protein, acyl-CoA binding domain containing 6 Protein, acyl-CoA binding protein Protein, acyl-CoA binding domain containing 6 S homeolog Protein, acyl-CoA-binding protein 6 Protein, acyl-Coenzyme A binding domain containing 6 Protein, LHX4-AS1 Protein, ACBD6 Protein, acbd6 Protein, Acbd6 Protein, acbd6.S Protein, ACBP6 Protein

Sujet:

Background: Acyl-coenzyme A binding domain-containing member 6 (ACBD6) is a modular protein that carries an acyl-CoA binding domain at its N terminus and two ankyrin motifs at its C terminus. In mammals, there are six members of the acyl-CoA binding domain-containing (ACBD) family, and their annotation is not uniform. All six ACBD proteins contain an ACB domain at the N terminus, but they do not share significant homology at the C-terminal region. ACBD6 is a 32 kDa protein that is predicted by sequence analysis to carry an ACB domain between residues 42 and 125 and two ANK motifs at its C terminus. This protein binds long-chain acyl-CoAs with a strong preference for unsaturated, C18:1-CoA and C20:4-CoA, over saturated, C16:0-CoA, acyl species. ACBD6 is not a ubiquitous protein, but it is expressed in hematopoietic tissues and appears to be restricted to primitive stem cells present in those tissues with functions in blood and vessel development. ACBD6 was detected in bone marrow, spleen, placenta, cord blood, circulating CD34+ progenitors, and embryonic-like stem cells derived from placenta. In placenta, the protein was only detected in CD34+ progenitor cells present in blood and in CD31+ endothelial cells surrounding the blood vessels. These cells were also positive for the marker CD133, and they probably constitute hemangiogenic stem cells, precursors of both blood and vessels. We propose that human ACBD6 represents a cellular marker for primitive progenitor cells with functions in hematopoiesis and vascular endothelium development.

Synonym: MGC2404,ACBD6

Poids moléculaire: 33.4 kDa

NCBI Accession: NP_115736