ACOX1 Protein (His tag)

N° du produit ABIN7317600

Détail du produit

Antigène: ACOX1 (Acyl-CoA Oxidase 1, Palmitoyl (ACOX1))

Type de proteíne: Recombinant

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette ACOX1 protéine est marqué à la His tag.

Fonction: Recombinant Human ACOX1/aox Protein (His Tag)

Séquence: Met 1-Leu 660

Attributs du produit: A DNA sequence encoding the human ACOX1 (AAH08767.1) (Met 1-Leu 660) was expressed, with a polyhistidine tag at the N-terminus.

Pureté: > 85 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.0, 20 % glycerol, 3 mM DTT

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: ACOX1 (Acyl-CoA Oxidase 1, Palmitoyl (ACOX1))

Autre désignation: ACOX1/aox (ACOX1 Produits)

Synonymes: zgc:92584 Protein, wu:fb59h12 Protein, zgc:114033 Protein, aco Protein, acox Protein, ACOX Protein, PALMCOX Protein, SCOX Protein, RATACOA1 Protein, AOX Protein, Acox Protein, D130055E20Rik Protein, Paox Protein, PCOX1 Protein, acyl-CoA oxidase 1 Protein, acyl-CoA oxidase 1, palmitoyl Protein, acyl-CoA oxidase 1, palmitoyl L homeolog Protein, acyl-Coenzyme A oxidase 1, palmitoyl Protein, ACOX1 Protein, acox1 Protein, acox1.L Protein, Acox1 Protein

Sujet:

Background: Peroxisomal acyl-coenzyme A oxidase 1(ACOX1 or AOX) is the first enzyme of the fatty acid beta-oxidation pathway and belongs to the Acyl-CoA oxidase family. Human liver peroxisomes contain two acyl-CoA oxidases, namely, palmitoyl-CoA oxidase (ACOX1/AOX) and a branched chain acyl-CoA oxidase. The palmitoyl-CoA oxidase (ACOX1/AOX) oxidizes the CoA esters of straight chain fatty acids and prostaglandins and donates electrons directly to molecular oxygen, thereby producing H2O2. Human ACOX1/AOX is a protein of 661-amino acids, including the carboxyl-terminal sequence(Ser-Lys-Leu) known as a minimal peroxisome-targeting signal. Human ACOX1/AOX, the first and rate-limiting enzyme of the peroxisomal β-oxidation pathway, has two isoforms including ACOX1a and ACOX1b, transcribed from a single gene. The human ACOX1b isoform is more effective than the ACOX1a isoform in reversing the Acox1 null phenotype in the mouse partly because of the Substrate utilization differences.

Synonym: ACOX;PALMCOX;SCOX

Poids moléculaire: 76.7 kDa

Pathways: Regulation of Lipid Metabolism by PPARalpha, Monocarboxylic Acid Catabolic Process