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AGRP Protein (His tag)

AGRP Origine: Humain Hôte: HEK-293 Cells Recombinant > 90 % as determined by reducing SDS-PAGE.
N° du produit ABIN7194186
  • Antigène Voir toutes AGRP Protéines
    AGRP (Agouti Related Protein Homolog (Mouse) (AGRP))
    Type de proteíne
    Recombinant
    Origine
    • 8
    • 4
    • 2
    • 1
    • 1
    Humain
    Source
    • 7
    • 4
    • 2
    • 2
    HEK-293 Cells
    Purification/Conjugué
    Cette AGRP protéine est marqué à la His tag.
    Fonction
    Recombinant Human AgRP/AGRP Protein (His Tag)
    Séquence
    Met 1-Thr 132
    Attributs du produit
    A DNA sequence encoding the human AgRP (NP_001129.1) (Met 1-Thr 132) was expressed,with a polyhistidine tag at the C-terminus.
    Pureté
    > 90 % as determined by reducing SDS-PAGE.
    niveau d'endotoxine
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product AGRP Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile PBS, pH 7.2
    Stock
    4 °C,-20 °C,-80 °C
    Stockage commentaire
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Antigène
    AGRP (Agouti Related Protein Homolog (Mouse) (AGRP))
    Autre désignation
    AgRP/AGRP (AGRP Produits)
    Synonymes
    AGRT Protein, ART Protein, ASIP2 Protein, Agrt Protein, Art Protein, agouti related neuropeptide Protein, agouti-related protein pseudogene Protein, AGRP Protein, Agrp Protein, LOC100352591 Protein
    Sujet

    Background: Agouti Related Protein (AGRP, or AGRT), is an endogenous antagonist of the melanocortin receptors MC3R and MC4R found in the hypothalamus and exhibits potent orexigenic activity. AGRP can act as a competitive antagonist to proopiomelanocortin (POMC)-derived peptides at the melanocortin-4 receptor (MC4R), and that this homeostatic mechanism is important as a means of coordinating appetite with perceived metabolic requirement. AGRP is upregulated by fasting while intracerebroventricular injections of synthetic AGRP lead to increased appetite and food intake. Thus, AGRP is a powerful orexigenic peptide that increases food intake when ubiquitously overexpressed or when administered centrally.

    Synonym: AGRT,ART,ASIP2

    Poids moléculaire
    14 kDa
    NCBI Accession
    NP_001129
    Pathways
    Feeding Behaviour, Photoperiodism
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