ATL1 Protein (GST tag)

N° du produit ABIN7194321

Détail du produit

Antigène: ATL1 (Atlastin GTPase 1 (ATL1))

Type de proteíne: Recombinant

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette ATL1 protéine est marqué à la GST tag.

Fonction: Recombinant Human ATL1/SPG3A/Atlastin-1 Protein (GST Tag)

Séquence: Met 1-Thr 447

Attributs du produit: A DNA sequence encoding the human SPG3A (NP_056999.2) (Met 1-Thr 447) was fused with the GST tag at the N-terminus.

Pureté: > 80 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 50 mM Tris, 100 mM NaCl, 0.5 mM PMSF, 0.5 mM EDTA, 0.5 mM GSH, pH 8.0

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: ATL1 (Atlastin GTPase 1 (ATL1))

Autre désignation: ATL1/SPG3A/Atlastin-1 (ATL1 Produits)

Synonymes: ATL1 Protein, SPG3A Protein, fj46c01 Protein, wu:fj46c01 Protein, spg3a Protein, MGC146251 Protein, AD-FSP Protein, FSP1 Protein, GBP3 Protein, HSN1D Protein, SPG3 Protein, atlastin1 Protein, 4930435M24Rik Protein, Adfsp Protein, Fsp1 Protein, Spg3 Protein, Spg3a Protein, atlastin Protein, Atlastin-1 Protein, atlastin GTPase 1 Protein, ATL1 Protein, atl1 Protein, Atl1 Protein

Sujet:

Background: Atlastin-1, also known as Spastic paraplegia 3 protein A, Guanine nucleotide-binding protein 3, GTP-binding protein 3, GBP3, ATL1 and SPG3A, is a multi-pass membrane protein which belongs to the GBP family and atlastin subfamily. ATL1 / SPG3A is expressed predominantly in the adult and fetal central nervous system. Expression of ATL1 / SPG3A in adult brain is at least 50-fold higher than in other tissues. ATL1 / SPG3A is detected predominantly in pyramidal neurons in the cerebral cortex and the hippocampus of the brain. ATL1 / SPG3A is also expressed in upper and lower motor neurons (at protein level). A distinguishing feature of ATL1 / SPG3A is its frequent early onset, raising the possibility that developmental abnormalities may be involved in its pathogenesis. Missense SPG3A mutant atlastin-1 proteins have impaired GTPase activity and may act in a dominant-negative, loss-of-function manner by forming mixed oligomers with wild-type atlastin-1. Defects in ATL1 / SPG3A are the cause of spastic paraplegia autosomal dominant type 3 (SPG3), also known as Strumpell-Lorrain syndrome. Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.

Synonym: AD-FSP;atlastin1;FSP1;GBP3;HSN1D;SPG3;SPG3A

Poids moléculaire: 77 kDa

NCBI Accession: NP_056999