B3GAT3 Protein (His tag)

N° du produit ABIN7319209

Détail du produit

Antigène: B3GAT3 (beta-1,3-Glucuronyltransferase 3 (Glucuronosyltransferase I) (B3GAT3))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette B3GAT3 protéine est marqué à la His tag.

Fonction: Recombinant Human B3GAT3 Protein (His Tag)

Séquence: Glu72-Val335

Attributs du produit: Recombinant Human Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 is produced by our E.coli expression system and the target gene encoding Glu72-Val335 is expressed with a 6His tag at the C-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM Tris,150 mM NaC,2 mM EDTA,20 % Glycerol, pH 8.0.

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: B3GAT3 (beta-1,3-Glucuronyltransferase 3 (Glucuronosyltransferase I) (B3GAT3))

Autre désignation: B3GAT3 (B3GAT3 Produits)

Synonymes: GLCATI Protein, 2810405M13Rik Protein, GlcUAT-I Protein, Glcat-i Protein, beta-1,3-glucuronyltransferase 3 Protein, beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I) Protein, B3GAT3 Protein, B3gat3 Protein

Sujet:

Background: Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 (B3GAT3) is an enzyme that in humans is encoded by the B3GAT3 gene, belongs to the glycosyltransferase 43 family. B3GAT3 is involved in a number of biological processes such as catalyzing the formation of the glycosaminoglycan-protein linkage by way of a glucuronyl transfer reaction in the final step of the biosynthesis of the linkage region of proteoglycans, forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate, gGlycosaminoglycans biosynthesis, transfering a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4-Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans.It also plays a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins , hows strict specificity for Gal-beta-1,3-Gal-beta-1,4-Xyl, exhibiting negligible incorporation into other galactoside substrates including Galbeta1-3Gal beta1-O-benzyl, Galbeta1-4GlcNAc and Galbeta1-4Glc and stimulates 2-phosphoxylose phosphatase activity of PXYLP1 in presence of uridine diphosphate-glucuronic acid (UDP-GlcUA) during completion of linkage region formation.

Synonym: B3GAT3,Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3,Beta-1,3-glucuronyltransferase 3,Glucuronosyltransferase I,GlcAT-I,GlcUAT-I,Gal beta-1,3-Gal-R glucuronyltransferase,

Poids moléculaire: 30.4 kDa

UniProt: O94766

Pathways: Glycosaminoglycan Metabolic Process