BACE2 Protein (His tag)

N° du produit ABIN7194384

Détail du produit

Antigène: BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette BACE2 protéine est marqué à la His tag.

Fonction: Recombinant Mouse BACE2/Beta secretase 2 Protein (His Tag)(Active)

Séquence: Met1-Pro462

Attributs du produit: A DNA sequence encoding the mouse BACE2 (Q9JL18) (Met1-Pro462) was expressed with a C-terminal polyhistidine tag.

Pureté: > 95 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Measured by its ability to cleave a fluorogenic peptide substrate Mca-KPLGL-Dpa-AR-NH2 .The specific activity is >50 pmoles/min/μg.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))

Autre désignation: BACE2/Beta secretase 2 (BACE2 Produits)

Synonymes: AEPLC Protein, ALP56 Protein, ASP1 Protein, ASP21 Protein, BAE2 Protein, CEAP1 Protein, DRAP Protein, 1110059C24Rik Protein, AI850424 Protein, ARP1 Protein, CDA13 Protein, beta-site APP-cleaving enzyme 2 Protein, BACE2 Protein, Bace2 Protein

Sujet:

Background: BACE2, also known as beta secretase 2, belongs to the peptidase A1 family. It is a protease known to be an important enzyme involved in the cellular pathways. BACE2 has been shown to interact with GGA1 and GGA2. It is the major β-secretase in vivo. BACE2 is located on chromosome 21 and may play a role in alzheimer's disease pathogenesis in down syndrome(DS). Overexpression of BACE2 by lentivirus markedly reduced amyloid β protein production in primary neurons. Despite an extra copy of the BACE2 gene in DS and the increase of its transcription, BACE2 protein levels are unchanged.

Synonym: 1110059C24Rik;AEPLC;AI850424;ALP56;ARP1;ASP21;BAE2;CDA13;CEAP1;DRAP

Poids moléculaire: 49.2 kDa

UniProt: Q9JL18