BBOX1 Protein (GST tag,His tag)

N° du produit ABIN7317173

Détail du produit

Antigène: BBOX1 (butyrobetaine (Gamma), 2-Oxoglutarate Dioxygenase (Gamma-butyrobetaine Hydroxylase) 1 (BBOX1))

Type de proteíne: Recombinant

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette BBOX1 protéine est marqué à la GST tag,His tag.

Fonction: Recombinant Human BBOX1/Gamma-BBH Protein (His & GST Tag)

Séquence: Met 1-Asn387

Attributs du produit: A DNA sequence encoding the human BBOX1 (O75936) (Met1-Asn387) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Pureté: > 85 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 10 % glycerol, pH 8.0

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: BBOX1 (butyrobetaine (Gamma), 2-Oxoglutarate Dioxygenase (Gamma-butyrobetaine Hydroxylase) 1 (BBOX1))

Autre désignation: BBOX1/Gamma-BBH (BBOX1 Produits)

Synonymes: BBOX1 Protein, wu:fj14g08 Protein, zgc:112179 Protein, BBH Protein, BBOX Protein, G-BBH Protein, gamma-BBH Protein, Bbh Protein, Bbox Protein, AI874739 Protein, gamma-butyrobetaine hydroxylase 1 Protein, butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 Protein, gamma-butyrobetaine dioxygenase Protein, butyrobetaine (gamma), 2-oxoglutarate dioxygenase 1 (gamma-butyrobetaine hydroxylase) Protein, BBOX1 Protein, bbox1 Protein, LOC699465 Protein, Bbox1 Protein

Sujet:

Background: BBOX1, also known as gamma-BBH, belongs to the gamma-BBH/TMLD family. It is highly expressed in kidney and moderately expressed in liver. BBOX1 catalyzes the formation of L-carnitine from gamma-butyrobetaine, the last step in the L-carnitine biosynthetic pathway. Carnitine is essential for the transport of activated fatty acids across the mitochondrial membrane during mitochondrial beta-oxidation. BBOX1 is an inhibition target for mildronate which can be used to treat angina andmyocardial infarction. Mildronate may also be beneficial for the treatment ofneurological disorder, diabetes, and seizures and alcohol intoxication.

Synonym: BBH;BBOX;G-BBH;gamma-BBH

Poids moléculaire: 72.5 kDa

UniProt: O75936