BTN2A2 Protein (Fc Tag)

N° du produit ABIN7319680

Détail du produit

Antigène: BTN2A2 (butyrophilin, Subfamily 2, Member A2 (BTN2A2))

Type de proteíne: Recombinant

Origine: Humain

Source: Human Cells

Purification/Conjugué: Cette BTN2A2 protéine est marqué à la Fc Tag.

Fonction: Recombinant Human BTN2A2 Protein (Fc Tag)

Séquence: Gln33-Val237

Attributs du produit: Recombinant Human BTN2A2 is produced by our Mammalian expression system and the target gene encoding Gln33-Val237 is expressed with a Fc tag at the C-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: BTN2A2 (butyrophilin, Subfamily 2, Member A2 (BTN2A2))

Autre désignation: BTN2A2 (BTN2A2 Produits)

Synonymes: BT2.2 Protein, BTF2 Protein, Btn2 Protein, D030063K05 Protein, btf2 Protein, bt2.2 Protein, MGC88971 Protein, BTN2A2 Protein, BTN2A1 Protein, butyrophilin subfamily 2 member A2 Protein, butyrophilin, subfamily 2, member A2 Protein, butyrophilin subfamily 2 member A2 L homeolog Protein, BTN2A2 Protein, Btn2a2 Protein, btn2a2 Protein, btn2a2.L Protein, LOC100065830 Protein, LOC100348076 Protein

Sujet:

Background: Butyrophilin 2A2 (BTN2A2) is a widely expressed type I transmembrane glycoprotein that functions as a negative regulator of immune responses. Mature human Butyrophilin 2A2 consisits of a 233 amino acid (aa) extracellular domain with two immunoglobulin-like domains, a 21 aa transmembrane segment, and a 237 aa cytoplasmic domain. Alternative splicing generates additional isoforms of human Butyrophilin 2A2 that lack the first, second, or both Iglike domains as well as isoforms with substitutions and deletions in the cytoplasmic region. Within the immune system, Butyrophilin 2A2 is expressed on thymic epithelial cells, na?ve B cells, splenic NK cells, dendritic cells, and peritoneal macrophages and is up-regulated with cell activation. Butyrophilin 2A2 inhibits T cell proliferation and activation and enhances the development of FoxP3+ regulatory T cells. Its up-regulation in the hippocampus is associated with schizophrenia.

Synonym: Butyrophilin subfamily 2 member A2, BTN2A2

Poids moléculaire: 49.7 kDa

UniProt: Q8WVV5

Pathways: Activated T Cell Proliferation