Cadherin 5 Protein (CDH5) (Fc Tag)
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- Antigène Voir toutes Cadherin 5 (CDH5) Protéines
- Cadherin 5 (CDH5)
- Type de proteíne
- Recombinant
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Origine
- Rat
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette Cadherin 5 protéine est marqué à la Fc Tag.
- Fonction
- Recombinant Rat VE-Cadherin/CDH5 Protein (Fc Tag)
- Séquence
- Met1-Gln585
- Attributs du produit
- A DNA sequence encoding the rat CDH5 (NP_001100877.1) (Met1-Gln585) was expressed with a polyhistidine tag at the C-terminus.
- Pureté
- > 75 % as determined by SDS-PAGE
- niveau d'endotoxine
- < 1.0 EU per μg of the protein as determined by the LAL method
- Top Product
- Discover our top product CDH5 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Antigène
- Cadherin 5 (CDH5)
- Autre désignation
- VE-Cadherin/CDH5 (CDH5 Produits)
- Synonymes
- 7B4 Protein, AA408225 Protein, Cd144 Protein, VE-Cad Protein, VECD Protein, VEcad Protein, Vec Protein, wu:fc88a07 Protein, CD144 Protein, cadherin-5 Protein, cadherin 5 Protein, CDH5 Protein, Cdh5 Protein, cdh5 Protein
- Sujet
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Background: Cadherins (Calcium dependent adhesion molecules) are a class of transmembrane proteins. Cadherin-5, also known as VE-cadherin, CDH5 and CD144, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. VE-Cadherin is widely considered to be specific for vascular endothelia in which it is either the sole or the predominant cadherin, often co-existing with N-cadherin. This specificity of VE-cadherin for vascular endothelial cells is important not only in blood and lymph vessel biology and medicine, but also for cell-type-based diagnoses, notably those of metastatic tumors. As a classical cadherin, VE-Cadherin links endothelial cells together by homophilic interactions mediated by its extracellular part and associates intracellularly with the actin cytoskeleton via catenins. Mechanisms that regulate VE-cadherin-mediated adhesion are important for the control of vascular permeability and leukocyte extravasation. In addition to its adhesive functions, VE-Cadherin regulates various cellular processes such as cell proliferation and apoptosis and modulates vascular endothelial growth factor receptor functions. Consequently, VE-cadherin is essential during embryonic angiogenesis.
Synonym: CDH5
- Poids moléculaire
- 90.7 kDa
- NCBI Accession
- NP_001100877
- Pathways
- Cell-Cell Junction Organization, Signaling Events mediated by VEGFR1 and VEGFR2
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