CALML5 Protein (GST tag,His tag)

N° du produit ABIN7317487

Détail du produit

Antigène: CALML5 (Calmodulin-Like 5 (CALML5))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette CALML5 protéine est marqué à la GST tag,His tag.

Fonction: Recombinant Human CALML5/CLSP Protein (His & GST Tag)

Séquence: Met 1-Glu 146

Attributs du produit: A DNA sequence encoding the human CALML5 (AAH39172.1) (Met 1-Glu 146) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Pureté: > 92 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 150 mM NaCl, 1 mM DTT, 0.5 mM GSH, 10 % glycerol, pH 7.8

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: CALML5 (Calmodulin-Like 5 (CALML5))

Autre désignation: CALML5/CLSP (CALML5 Produits)

Synonymes: CALML5 Protein, CLSP Protein, F14B2.33 Protein, multicopy suppressors of snf4 deficiency in yeast 3 Protein, calmodulin like 5 Protein, calmodulin-like 5 Protein, Calcium-binding EF-hand family protein Protein, CALML5 Protein, MSS3 Protein

Sujet:

Background: Calmodulin-like protein 5, also known as Calmodulin-like skin protein, CALML5 and CLSP, is a protein which contains four EF-hand domains. CALML5 / CLSP is particularly abundant in the epidermis where its expression is directly related to keratinocyte differentiation.The expression is very low in lung. CALML5 / CLSP binds calcium. It may be involved in terminal differentiation of keratinocytes. Coxsackievirus and adenovirus receptor (CAR) is a member of the immunoglobulin (Ig) superfamily and a component of epithelial tight junction. CAR functions as a primary receptor for coxsackievirus B and adenovirus (Ad) infection. CALML5 / CLSP is closely related to CAR. The structure and dynamics of human calmodulin-like skin protein CALML5 / CLSP have been characterized by NMR spectroscopy. The mobility of CALML5 / CLSP has been found to be different for the N-terminal and C-terminal domains. The N-terminal domain is characterized by four stable helices, which experience large fluctuations. This is shown to be due to mutations in the hydrophobic core. The overall N-terminal domain behavior is similar both in the full-length protein and in the isolated domain.

Synonym: CLSP

Poids moléculaire: 44.2 kDa

Pathways: Phototransduction