CHST3 Protein (His tag)

N° du produit ABIN7320226

Détail du produit

Antigène: CHST3 (Carbohydrate (Chondroitin 6) Sulfotransferase 3 (CHST3))

Type de proteíne: Recombinant

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette CHST3 protéine est marqué à la His tag.

Fonction: Recombinant Mouse CHST3/C6ST-1 Protein (His Tag)

Séquence: Glu 39-Thr 472

Attributs du produit: A DNA sequence encoding the extracellular domain of mouse CHST3 (NP_058083.2) (Glu 39-Thr 472) was fused with a polyhistidine tag at the N-terminus.

Pureté: > 95 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: CHST3 (Carbohydrate (Chondroitin 6) Sulfotransferase 3 (CHST3))

Autre désignation: CHST3/C6ST-1 (CHST3 Produits)

Synonymes: C6ST Protein, C6ST1 Protein, HSD Protein, C6ST-1 Protein, GST-0 Protein, carbohydrate sulfotransferase 3 Protein, carbohydrate (chondroitin 6/keratan) sulfotransferase 3 Protein, CHST3 Protein, Chst3 Protein

Sujet:

Background: Carbohydrate sulfotransferase 3, also known as Chondroitin 6-O-sulfotransferase 1, Chondroitin 6-sulfotransferase and CHST3, is a single-pass type I I membrane protein which belongs to the sulfotransferase 1 family and Gal / GlcNAc / GalNAc subfamily. CHST3 is widely expressed in adult tissues. It is expressed in heart, placenta, skeletal muscle and pancreas. CHST3 is also expressed in various immune tissues such as spleen, lymph node, thymus and appendix. CHST3 catalyzes the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. It is a chondroitin sulfate which constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. It can also sulfate Gal residues of keratan sulfate, another glycosaminoglycan, and the Gal residues in sialyl N-acetyllactosamine (sialyl LacNAc) oligosaccharides. It may play a role in the maintenance of naive T-lymphocytes in the spleen. Defects in CHST3 are the cause of spondyloepiphyseal dysplasia Omani type (SED Omani type) which is an autosomal recessive disorder characterized by normal length at birth but severely reduced adult height (110-130 cm), severe progressive kyphoscoliosis, arthritic changes with joint dislocations, genu valgum, cubitus valgus, mild brachydactyly, camptodactyly, microdontia and normal intelligence. As a consequence of the arthropathy and the contractures, affected individuals develop restricted joint movement. Defects in CHST3 are also a cause of humerospinal dysostosis (HSD) which is characterized by bifurcation of the ends of the humerus, subluxation in the elbow joints, widened iliac bones, talipes equinovarus and coronal cleft vertebrae. Congenital, progressive heart disease, possibly with fatal outcome, is observed in some patients.

Synonym: C6ST;C6ST-1;GST-0

Poids moléculaire: 52 kDa

NCBI Accession: NP_058083

Pathways: Glycosaminoglycan Metabolic Process