CPB2 Protein (His tag)

N° du produit ABIN7321061

Détail du produit

Antigène: CPB2 (Carboxypeptidase B2 (Plasma) (CPB2))

Type de proteíne: Recombinant

Origine: Rat

Source: HEK-293 Cells

Purification/Conjugué: Cette CPB2 protéine est marqué à la His tag.

Fonction: Recombinant Rat Carboxypeptidase B2/CPB2 Protein (His Tag)

Séquence: Met1-Ser422

Attributs du produit: A DNA sequence encoding the rat Cpb2 (NP_446069.1) (Met1-Ser422) was expressed with a polyhistidine tag at the C-terminus.

Pureté: > 95 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg protein as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: CPB2 (Carboxypeptidase B2 (Plasma) (CPB2))

Autre désignation: Carboxypeptidase B2/CPB2 (CPB2 Produits)

Synonymes: CPU Protein, PCPB Protein, TAFI Protein, 1110032P04Rik Protein, 4930405E17Rik Protein, AI255929 Protein, CPR Protein, Cpu Protein, pCPB Protein, zgc:112493 Protein, carboxypeptidase B2 Protein, carboxypeptidase B2 (plasma) Protein, CPB2 Protein, Cpb2 Protein, cpb2 Protein

Sujet:

Background: Carboxypeptidase B2, also known as Carboxypeptidase U, Thrombin-activable fibrinolysis inhibitor, Plasma carboxypeptidase B, CPB2, is a secreted protein which belongs to the peptidase M14 family. Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). CPB2 is activated by thrombin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. CPB2 is synthesized by the liver and circulates in the plasma as a plasminogen-bound zymogen. When it is activated by proteolysis at residue Arg92 by the thrombin / thrombomodulin complex. CPB2 cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. CPB2 exhibits carboxypeptidase activity and activated CPB2 reduces fibrinolysis by removing the fibrin C-terminal residues that are important for the binding and activation of plasminogen.

Synonym: CPB2

Poids moléculaire: 48 kDa

NCBI Accession: NP_446069

Pathways: Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis