CD180 Protein (His tag)

N° du produit ABIN7320258

Détail du produit

Antigène: CD180 (CD180 Molecule (CD180))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette CD180 protéine est marqué à la His tag.

Fonction: Recombinant Mouse CD180/RP105/LY64 Protein (His Tag)(Active)

Séquence: Met 1-Ser 626

Attributs du produit: A DNA sequence encoding the mouse CD180 (NP_032559.2) extracellular domain (Met 1-Ser 626) was expressed, fused with a polyhistidine tag at the C-terminus.

Pureté: > 92 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Measured by its binding ability in a functional ELISA. Immobilized mouse CD180 at 2 μg/ml (100 μl/well) can bind biotinylated mouse MD-1 with a linear ranger of 6.25-50 μg/ml.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: CD180 (CD180 Molecule (CD180))

Autre désignation: CD180/RP105/LY64 (CD180 Produits)

Synonymes: Ly78 Protein, CD180 Protein, LY64 Protein, RP105 Protein, F630107B15 Protein, CD180 molecule Protein, CD180 antigen Protein, Cd180 Protein, CD180 Protein

Sujet:

Background: The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD180, also known as RP105, is a B-cell surface molecule belonging to the family of pathogen receptors, Toll-like receptors (TLR). CD180 has an extracellular leucine-rich repeats and a short cytoplasmic tail. CD180 / RP105 interact with an extracellular molecule named MD1 and then together form the cell surface receptor complex RP105 / MD1 which induces B-cell activation in humans and mice, leading to proliferation and up-regulation of a costimulatory molecule, B7.2 / CD86. CD180 / RP105 also has a role in LPS response because B cells lacking RP105 show hyporesponsiveness to LPS.

Synonym: F630107B15,Ly78,RP105

Poids moléculaire: 69.4 kDa

NCBI Accession: NP_032559

Pathways: Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades