CREG1 Protein (His tag)

N° du produit ABIN7320632

Détail du produit

Antigène: CREG1 (Cellular Repressor of E1A-Stimulated Genes 1 (CREG1))

Type de proteíne: Recombinant

Origine: Souris

Source: Human Cells

Purification/Conjugué: Cette CREG1 protéine est marqué à la His tag.

Fonction: Recombinant Mouse CREG/CREG1 Protein (His Tag)

Séquence: Arg32-Gln220

Attributs du produit: Recombinant Mouse Cellular Repressor of E1A-stimulated Genes is produced by our Mammalian expression system and the target gene encoding Arg32-Gln220 is expressed with a 6His tag at the C-terminus.

Pureté: > 95 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: CREG1 (Cellular Repressor of E1A-Stimulated Genes 1 (CREG1))

Autre désignation: CREG/CREG1 (CREG1 Produits)

Synonymes: CREG1 Protein, CREG Protein, AA755314 Protein, Creg Protein, cellular repressor of E1A stimulated genes 1 Protein, cellular repressor of E1A-stimulated genes 1 Protein, CREG1 Protein, creg1 Protein, Creg1 Protein

Sujet:

Background: Cellular repressor of E1A genes (CREG) is an evolutionarily conserved lysosomal protein, and an important new factor in regulating tissue homeostasis that has been shown to antagonize injury of tissues or cells. CREG contains three mannose 6-phosphate (M6P) markers, and depends on interactions with M6P receptors for efficient delivery to lysosomes, which is implicated in the regulation of lysosomal functions. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. CREG plays an important role in the control of cell growth and differentiation. It has been shown that CREG antagonizes transcriptional and cellular transformation by the adenoviral E1A oncoprotein, induces differentiation while attenuating cellular proliferation, regulates the levels of the signaling kinases ERK1/2, and mediates glucocorticoid-induced proliferation of ileal epithelial cells. CREG is widely expressed in adult tissues, such as the brain, heart, lungs, liver, intestines and kidneys in mice, but is not markedly expressed in pluripotent embryonic stem cells.

Synonym: CREG1, cellular repressor of E1A-stimulated genes, cellular repressor of E1A-stimulated genes 1CREG, protein CREG1

Poids moléculaire: 22.5 kDa

UniProt: O88668