CER1 Protein (His tag)

N° du produit ABIN7318301

Détail du produit

Antigène: CER1 (Cerberus 1 Homolog (Xenopus Laevis) (CER1))

Type de proteíne: Recombinant

Origine: Humain

Source: Human Cells

Purification/Conjugué: Cette CER1 protéine est marqué à la His tag.

Fonction: Recombinant Human Cerberus/CER1 Protein (His Tag)

Séquence: Thr18-Ala267

Attributs du produit: Recombinant Human Cerberus 1 is produced by our Mammalian expression system and the target gene encoding Thr18-Ala267 is expressed with a 6His tag at the C-terminus.

Pureté: > 90 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM HAc.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: CER1 (Cerberus 1 Homolog (Xenopus Laevis) (CER1))

Autre désignation: Cerberus/CER1 (CER1 Produits)

Synonymes: DAND4 Protein, CAR Protein, cer Protein, cer-1 Protein, dand4 Protein, tCerberus Protein, xcer-1 Protein, xcer1 Protein, Cerl Protein, Cerl1 Protein, Cerr1 Protein, RGD1563046 Protein, cerberus 1, DAN family BMP antagonist Protein, cerberus 1, DAN family BMP antagonist S homeolog Protein, CER1 Protein, cer1.S Protein, Cer1 Protein

Sujet:

Background: Cerberus 1 is a secreted glycoprotein that forms disulfide-linked homodimers. It is a cytokine member of the DAN domain family of BMP antagonists that includes DAN (DAND1), Gremlin/Drm (DAND2), PRDC (Protein Related to Dan and Cerberus, DAND3), and COCO/Dante (DAND5). DAN family members contain a cysteine knot domain that is homologous to that found in other TGF-beta superfamily ligands. At the onset of gastrulation, Cerberus 1 is transiently expressed in anterior endodermal structures in response to Nodal and Shh. Cerberus 1 binds BMP-4 and Nodal and inhibits their activities. The inhibitory functions of Cerberus favor mesodermal development in the anterior region of the gastrula and suppresses posterior mesodermal differentiation. In chick and Xenopus, Cerberus 1 also regulates, but is not required for embryonic left-right polarization, neurulation, and head and heart induction.

Synonym: Cerberus, Cerberus-Related Protein, DAN Domain Family Member 4, CER1, DAND4

Poids moléculaire: 29.2 kDa

UniProt: O95813

Pathways: Maintenance of Protein Location