CMA1 Protein (His tag)

N° du produit ABIN7195123

Détail du produit

Antigène: CMA1 (Chymase 1, Mast Cell (CMA1))

Type de proteíne: Recombinant

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette CMA1 protéine est marqué à la His tag.

Fonction: Recombinant Human CMA1/Chymase 1 Protein (His Tag)

Séquence: Met 1-Asn 247

Attributs du produit: A DNA sequence encoding the human CMA1 (P23946) (Met 1-Asn 247) was fused with a polyhistidine tag at the C-terminus.

Pureté: > 92 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: CMA1 (Chymase 1, Mast Cell (CMA1))

Autre désignation: CMA1/Chymase 1 (CMA1 Produits)

Synonymes: CYH Protein, MCT1 Protein, chymase Protein, MMCP-5 Protein, Mcp-5 Protein, Mcp5 Protein, Mcpt5 Protein, MCP3P Protein, CMA1 Protein, Chymase Protein, chymase 1 Protein, chymase 1, mast cell Protein, chymase-like Protein, CMA1 Protein, Cma1 Protein, LOC100008644 Protein

Sujet:

Background: Chymotrypsin C (abbreviated for CTRC), also known as caldecrin or elastase4, is a digestive enzyme of the peptidase S1 family. This enzyme is synthesized as an inactivate chymotrypsinogen. On cleavage by trypsin into two parts that activate each other by removing two small peptides in a trans-proteolysis, chymotrypsin C produced. N-linked glycosylation of human CTRC is required for efficient folding and secretion, however, the N-linked glycan is unimportant for enzyme activity or inhibitor binding. It has been proposed that CTRC is a key regulator of digestive zymogen activation and a physiological co-activator of digestive carboxypeptidases proCPA1 and proCPA2. Mutations that abolish activity or secretion of CTRC increase the risk for chronic pancreatitis. It's speculated that CTRC might regulate pancreatic cancer cell migration in relation to cytokeratin 18 expression. The pancreatic cancer cell migration ability was downregulated in pancreatic cancer Aspc-1 cells that overexpressed CTRC, whereas the cell migration ability was upregulated in Aspc-1 cells in which CTRC was suppressed. 

Synonym: chymase;CYH;MCT1

Poids moléculaire: 26.6 kDa

UniProt: P23946

Pathways: ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Carbohydrate Homeostasis