Coagulation Factor IX Protein (F9) (His tag)

N° du produit ABIN7318321

Détail du produit

Antigène: Coagulation Factor IX (F9)

Type de proteíne: Recombinant

Origine: Humain

Source: Human Cells

Purification/Conjugué: Cette Coagulation Factor IX protéine est marqué à la His tag.

Fonction: Recombinant Human Coagulation Factor IX/F9 Protein (His Tag)

Séquence: Thr 29-Thr461

Attributs du produit: Recombinant Human Coagulation factor IX is produced by our Mammalian expression system and the target gene encoding Thr29-Thr461 is expressed with a 6His tag at the C-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl,150 mM NaCl,10 % Glycerol, pH 8.0.

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: Coagulation Factor IX (F9)

Autre désignation: Coagulation Factor IX/F9 (F9 Produits)

Synonymes: AA407498 Protein, AI506714 Protein, AK-3 Protein, Ak3l Protein, Ak3l1 Protein, Akl3l Protein, FIX Protein, HEMB Protein, P19 Protein, PTC Protein, THPH8 Protein, AW111646 Protein, Cf-9 Protein, Cf9 Protein, f9 Protein, zgc:109775 Protein, fix Protein, ptc Protein, hemb Protein, FIXA Protein, zgc:136807 Protein, adenylate kinase 3 Protein, coagulation factor IX Protein, coagulation factor IXa Protein, coagulation factor 9 Protein, coagulation factor 9 S homeolog Protein, Coagulation factor IX Protein, coagulation factor IXb Protein, Ak3 Protein, F9 Protein, f9a Protein, f9 Protein, CpipJ_CPIJ003776 Protein, CpipJ_CPIJ009129 Protein, CpipJ_CPIJ013063 Protein, CpipJ_CPIJ013624 Protein, Tsp_01441 Protein, f9.S Protein, fa9 Protein, f9b Protein

Sujet:

Background: Coagulation factor IX(F9), is a member of the peptidase S1 family. It contains two EGF-like domains, a Gla domain and a peptidase S1 domain. It is primarily expressed in the liver and secreted in plasma. Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca2+ ions, phospholipids, and factor VIIIa. Mutations in position 43 and 46 prevents cleavage of the propeptide, mutation in position 93 probably fails to bind to cell membranes, mutation in position 191 or in position 226 prevent cleavage of the activation peptide. Mutations of human F9 can result in thrombophilia and recessive X-linked hemophilia B (HEMB). An X-linked blood coagulation disorder characterized by a permanent tendency to hemorrhage, due to factor IX deficiency. It is phenotypically similar to hemophilia A, but patients present with fewer symptoms. Many patients are asymptomatic until the hemostatic system is stressed by surgery or trauma.

Synonym: Coagulation factor 9,F9,Coagulation factor IX,Christmas factor,Plasma thromboplastin component,Coagulation factor IXa light chain,Coagulation factor IXa heavy chain,FIX,HEMB,P19,PTC,THPH8

Poids moléculaire: 49.8 kDa

UniProt: P00740