CRHBP Protein (His tag)

N° du produit ABIN7318339

Détail du produit

Antigène: CRHBP (Corticotropin Releasing Hormone Binding Protein (CRHBP))

Type de proteíne: Recombinant

Origine: Humain

Source: Human Cells

Purification/Conjugué: Cette CRHBP protéine est marqué à la His tag.

Fonction: Recombinant Human CRHBP Protein (His Tag)

Séquence: Tyr25-Leu322

Attributs du produit: Recombinant Human Corticotropin-Releasing Factor-Binding Protein is produced by our Mammalian expression system and the target gene encoding Tyr25-Leu322 is expressed with a 6His tag at the C-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM TrisHCl, 150mm NaCl, pH 7.5.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: CRHBP (Corticotropin Releasing Hormone Binding Protein (CRHBP))

Autre désignation: CRHBP (CRHBP Produits)

Synonymes: crh-BP Protein, GB14094 Protein, zgc:91905 Protein, CRHBP Protein, CRH-BP Protein, CRF-BP Protein, CRFBP Protein, Crfbp Protein, crhbp-A Protein, gene E Protein, corticotropin releasing hormone binding protein Protein, corticotropin releasing hormone binding protein S homeolog Protein, CRHBP Protein, crhbp Protein, crh-BP Protein, Crhbp Protein, crhbp.S Protein

Sujet:

Background: Corticotropin-Releasing Factor-Binding Protein (CRHBP) is a 37 kDa secreted glycoprotein that binds both CRH and urocortin in a 42 kDa extracellular complex. The molecule is approximately 300 amino acids in length and demonstrates five intrachain disulfide bonds. Difference between CRHBP from different species exist, human CRHBP is found in plasma while rodent and sheep CRHBP is limited to neuroendocrine tissues. CRHBP may inactivate CRH and may prevent inappropriate pituitary-adrenal stimulation in pregnancy. CRHBP is presumed to either sequester CRH, rendering it unavailable to cells or transport it to target tissues. Although CRF-BP concentration in the human peripheral circulation is normally low, it increases throughout pregnancy and fall back rapidly after parturition.

Synonym: Corticotropin-Releasing Factor-Binding Protein, CRF-BP, CRF-Binding Protein, Corticotropin-Releasing Hormone-Binding Protein, CRH-BP, CRHBP, CRFBP

Poids moléculaire: 34.4 kDa

UniProt: P24387

Pathways: Negative Regulation of Hormone Secretion