CRLF2 Protein (Fc Tag)

N° du produit ABIN7319829

Détail du produit

Antigène: CRLF2 (Cytokine Receptor-Like Factor 2 (CRLF2))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: Human Cells

Purification/Conjugué: Cette CRLF2 protéine est marqué à la Fc Tag.

Fonction: Recombinant Human TSLP R/CRLF2 (C-Fc)

Séquence: Gly25-Lys231

Attributs du produit: Recombinant Human CRLF2 is produced by our Mammalian expression system and the target gene encoding Gly25-Lys231 is expressed with a Fc tag at the C-terminus.

Pureté: >95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: Loaded Human TSLP-His(Cat#C00K) on HIS1K Biosensor, can bind Human TSLP R-Fc(Cat#CW56) with an affinity constant of 37.97nM as determined in BLI assay.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: CRLF2 (Cytokine Receptor-Like Factor 2 (CRLF2))

Autre désignation: TSLP R/CRLF2 (CRLF2 Produits)

Synonymes: CRLF2 Protein, CRL2 Protein, CRLF2Y Protein, TSLPR Protein, CRLM2 Protein, Ly114 Protein, Tpte2 Protein, Tslpr Protein, Crl2 Protein, cytokine receptor like factor 2 Protein, cytokine receptor-like factor 2 Protein, CRLF2 Protein, Crlf2 Protein

Sujet:

Background: Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system. TSLP R expression is ubiquitous in the immune and hematopoietic cells, but is up-regulated in Th2-skewed cells. Cells expressing TSLP R alone bind TSLP with low affinity. Co-expression of TSLP R and IL-7 R alpha is required for high-affinity TSLP binding and signal transduction . The TSLP R and IL-7 R alpha are coexpressed primarily on monocytes and dendritic cells and at lower levels in lymphoid cells. TSLP has been shown to induce the release of T cell-attracting chemokines from monocytes and enhance the maturation of CD11c+ dendritic cells.

Synonym: CRL2, CRL2cytokine receptor CRL2 precusor, CRLF2, CRLF2Y, CRLM-2, Cytokine receptor-like 2,cytokine receptor-like factor 2, ILXR, IL-XR, P2RY8/CRLF2 fusion, PCOR1, TSLP R, TSLP receptor,TSLPR

Poids moléculaire: 50.9 kDa

UniProt: Q9HC73