DMBT1 Protein (His tag)

N° du produit ABIN7317505

Détail du produit

Antigène: DMBT1 (Deleted in Malignant Brain Tumors 1 (DMBT1))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette DMBT1 protéine est marqué à la His tag.

Fonction: Recombinant Human DMBT1/Muclin Protein (His Tag)(Active)

Séquence: Met 1-Ser 220

Attributs du produit: A DNA sequence encoding the N-terminal segment of human DMBT1 (NP_004397.2) (Met 1-Ser 220) was expressed, fused with a polyhistidine tag at the C-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: 1. Measured by its binding ability in a functional ELISA.2. Immobilized recombinant human Galectin-3 at 10 μg/ml (100 μl/well) can bind biotinylated DMBT1-His with a linear range of 0.06-1.0 μg/ml.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: DMBT1 (Deleted in Malignant Brain Tumors 1 (DMBT1))

Autre désignation: DMBT1/Muclin (DMBT1 Produits)

Synonymes: GP340 Protein, muclin Protein, CRP Protein, CRP-[a] Protein, CRP-[b] Protein, Crpd Protein, DBMT1 Protein, gp300 Protein, p80 Protein, DMBT1 Protein, gp340 Protein, deleted in malignant brain tumors 1 Protein, deleted in malignant brain tumors 1 protein Protein, gp340 Protein, deleted in malignant brain tumors 1 S homeolog Protein, DMBT1 Protein, Dmbt1 Protein, LOC100064515 Protein, dmbt1 Protein, ST201phi2-1p340 Protein, dmbt1.S Protein

Sujet:

Background: Deleted in malignant brain tumors 1 protein, also known as glycoprotein 340, surfactant pulmonary-associated D-binding protein, DMBT1 and GP340, is a secreted protein which belongs to the DMBT1 family. DMBT1 contains 2 CUB domains, 14 SRCR domains and 1 ZP domain. It is highly expressed in alveolar and macrophage tissues. In some macrophages, expression is detected on the membrane, and in other macrophages, it is strongly expressed in the phagosome/phagolysosome compartments. Defects in DMBT1 are involved in the development of glioma (GLM). Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas , and ependymomas.  DMBT1 may be considered as a candidate tumor suppressor for brain, lung, esophageal, gastric, and colorectal cancers. It may play roles in mucosal defense system, cellular immune defense and epithelial differentiation. DMBT1 may play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. It may be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. DMBT1 may function as a binding protein in saliva for the regulation of taste sensation. It binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission.

Synonym: GP340;muclin

Poids moléculaire: 22.6 kDa

NCBI Accession: NP_004397

Pathways: Activation of Innate immune Response