Doublecortin Protein (DCX) (GST tag)

N° du produit ABIN7317238

Détail du produit

Antigène: Doublecortin (DCX)

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette Doublecortin protéine est marqué à la GST tag.

Fonction: Recombinant Human DCX Protein (aa 45-150, GST Tag)

Séquence: Ala 45-Val 150

Attributs du produit: A DNA sequence encoding the human DCX (O43602-2) N-terminal fragment (Ala 45-Val 150) was fused with the GST tag at the N-terminus.

Pureté: > 82 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 1 mM DTT, 10 % glycerol, pH 7.5

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: Doublecortin (DCX)

Autre désignation: DCX (DCX Produits)

Synonymes: DCX Protein, DBCN Protein, DC Protein, LISX Protein, SCLH Protein, XLIS Protein, Dbct Protein, 18C15.5 Protein, doublecortin Protein, DCX Protein, Dcx Protein

Sujet:

Background: DCX (doublecortin, N-GST chimera)contains 2 doublecortin domains and belongs to the doublecortin family. It is highly expressed in neuronal cells of fetal brain, but not expressed in other fetal tissues. In the adult, it is highly expressed in the brain frontal lobe, but very low expression in other regions of brain, and not detected in heart, placenta, lung, liver, skeletal muscles, kidney and pancreas. DCX is a microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. It may act by competing with the putative neuronal protein kinase DCAMKL1 in binding to a target protein. DCX may in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. It may be part with LIS-1 of a overlapping, but distinct, signaling pathways that promote neuronal migration. Defects in DCX are the cause of lissencephaly X-linked type 1 and subcortical band heterotopia X-linked.

Synonym: DBCN,DC,LISX,SCLH,XLIS

Poids moléculaire: 39.4 kDa