DCLK1 Protein (AA 1-705) (GST tag,His tag)
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- Antigène Voir toutes DCLK1 Protéines
- DCLK1 (Doublecortin-Like Kinase 1 (DCLK1))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
- Attributs du protein
- AA 1-705
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Origine
- Humain
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Source
- Baculovirus infected Insect Cells
- Purification/Conjugué
- Cette DCLK1 protéine est marqué à la GST tag,His tag.
- Fonction
- Recombinant Human DCAMKL1 Protein (aa 1-705, His & GST Tag)(Active)
- Séquence
- Met 1-Val 705
- Attributs du produit
- A DNA sequence encoding the human DCLK1 (O15075-1) (Met 1-Val 705) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
- Pureté
- > 84 % as determined by reducing SDS-PAGE.
- niveau d'endotoxine
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- The specific activity was determined to be 6.1 nmol/min/mg using synthetic Autocamtide-2 peptide (KKALRRQETVDAL-amide) as substrate.
- Top Product
- Discover our top product DCLK1 Protéine
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- Restrictions
- For Research Use only
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- Format
- Frozen, Liquid
- Buffer
- Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol, 0.5 mM PMSF
- Stock
- -20 °C
- Stockage commentaire
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- Antigène
- DCLK1 (Doublecortin-Like Kinase 1 (DCLK1))
- Autre désignation
- DCAMKL1 (DCLK1 Produits)
- Synonymes
- DCLK1 Protein, DCAMKL1 Protein, dcamkl1 Protein, dclk1 Protein, wu:fc51f11 Protein, zgc:153709 Protein, MGC145348 Protein, CL1 Protein, CLICK1 Protein, DCDC3A Protein, DCLK Protein, 1700113D08Rik Protein, 2810480F11Rik Protein, AI836758 Protein, Click-I Protein, Cpg16 Protein, Dcamkl1 Protein, Dcl Protein, Dclk Protein, mKIAA0369 Protein, Ania4 Protein, doublecortin like kinase 1 Protein, doublecortin-like kinase 1a Protein, serine/threonine-protein kinase DCLK1 Protein, doublecortin-like kinase 2 Protein, doublecortin-like kinase 1 Protein, DCLK1 Protein, dclk1a Protein, LOC587664 Protein, dclk2 Protein, LOC100539645 Protein, Dclk1 Protein
- Sujet
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Background: DCAMKL1, also known as DCLK1, is a member of the protein kinase superfamily and the doublecortin family. It contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. DCAMKL1 is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. Its microtubule-polymerizing activity is independent of its protein kinase activity. DCAMKL1 may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. It may also participate in functions of the mature nervous system.
Synonym: CL1,CLICK1,DCAMKL1,DCDC3A,DCLK
- Poids moléculaire
- 106 kDa
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