ERAP2 Protein (His tag)

N° du produit ABIN7195485

Détail du produit

Antigène: ERAP2 (Endoplasmic Reticulum Aminopeptidase 2 (ERAP2))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette ERAP2 protéine est marqué à la His tag.

Fonction: Recombinant Human LRAP/ERAP2 Protein (His Tag)(Active)

Séquence: Ala 56-Thr 960

Attributs du produit: A DNA sequence encoding the lumenal domain of human ERAP2 (NP_071745.1) (Ala 56-Thr 960) was expressed with a polyhistidine tag at the N-terminus.

Pureté: > 98 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: Measured by its ability to cleave the fluorogenic peptide substrate, Arg-7-amido-4-methylcoumarin (Arg-AMC). The specific activity is >50 pmoles/min/μg.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 12.5 mM Tris, 75 mM NaCl, pH 7.5, 50 % glycercol

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: ERAP2 (Endoplasmic Reticulum Aminopeptidase 2 (ERAP2))

Autre désignation: LRAP/ERAP2 (ERAP2 Produits)

Synonymes: L-RAP Protein, LRAP Protein, ERAP2 Protein, zgc:172163 Protein, endoplasmic reticulum aminopeptidase 2 Protein, ERAP2 Protein, erap2 Protein

Sujet:

Background: Leukocyte-derived arginine aminopeptidase (LRAP), also known as endoplasmic reticulum-aminopeptidase 2 (ERAP2), is the second identified aminopeptidase localized in the in the lumenal side of endoplasmic reticulum (ER) processing antigenic peptides presented to major histocompatibility complex (MHC) class I molecules. It is a 960-amino acid protein with significant homology to placental leucine aminopeptidase and adipocyte-derived leucine aminopeptidase. LRAP preferentially hydrolyzes the basic residues Arg and Lys, and contains the HEXXH(X)18E zinc-binding motif, which is the characteristic of the M1 family of zinc metallopeptidases which also includes PILS/ARTS1/ERAP1 and LNPEP/PLAP. Induced by interferon-gamma, LRAP is able to trim various MHC class I antigenic peptide precursors.

Synonym: FLJ23633,FLJ23701,FLJ23807,L-RAP,LRAP,LRAP.ERAP2

Poids moléculaire: 106 kDa

NCBI Accession: NP_071745