ESM1 Protein (His tag)
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- Antigène Voir toutes ESM1 Protéines
- ESM1 (Endothelial Cell-Specific Molecule 1 (ESM1))
- Type de proteíne
- Recombinant
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Origine
- Souris
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Source
- Baculovirus infected Insect Cells
- Purification/Conjugué
- Cette ESM1 protéine est marqué à la His tag.
- Fonction
- Recombinant Mouse ESM1/Endocan Protein (Baculovirus, His Tag)
- Séquence
- Met1-Arg184
- Attributs du produit
- A DNA sequence encoding the mouse TLR2 (Q9QYY7) (Met1-Arg184) was fused with a polyhistidine tag at the C-terminus.
- Pureté
- > 95 % as determined by SDS-PAGE
- niveau d'endotoxine
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Top Product
- Discover our top product ESM1 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 8.0, 10 % glycerol
- Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Antigène
- ESM1 (Endothelial Cell-Specific Molecule 1 (ESM1))
- Autre désignation
- ESM1/Endocan (ESM1 Produits)
- Synonymes
- ESM1 Protein, zgc:153027 Protein, 0610042H23Rik Protein, AV004503 Protein, ESM-1 Protein, Pg25 Protein, endocan Protein, endothelial cell specific molecule 1 Protein, endothelial cell-specific molecule 1 Protein, ESM1 Protein, esm1 Protein, Esm1 Protein
- Sujet
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Background: ESM1 is a secreted protein which is produced by adipocytes. It has been noticed that ESM1 may play some role in obesity-associated vascular disease since circulating ESM-1 levels are reduced in the overweight and obese. ESM1 is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of ESM1 gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. Recently, ESM1 has been described as a specific biomarker of tip cells during neoangiogenesis. Its expression has been shown to be increase in presence of pro-angiogenic growth factors such as VEGF or FGF-2. In hypervascularized cancers, overexpression of endocan has been detected by immunohistochemistry using monoclonal antibodies against ESM1.
Synonym: Endothelial cell-specific molecule 1, ESM-1, Esm1, Endocan
- Poids moléculaire
- 19.1 kDa
- UniProt
- Q9QYY7
- Pathways
- Growth Factor Binding
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