EPHA1 Protein (His tag)

N° du produit ABIN7195579

Détail du produit

Antigène: EPHA1 (Ephrin Type A Receptor 1 (EPHA1))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette EPHA1 protéine est marqué à la His tag.

Fonction: Recombinant Mouse EphA1 Protein (His Tag)(Active)

Séquence: Met 1-Glu 548

Attributs du produit: A DNA sequence encoding the extracellular domain of mouse EPHA1 (Q60750) (Met 1-Glu 548) was expressed, with a C-terminal polyhistidine tag.

Pureté: > 97 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Measured by its binding ability in a functional ELISA. Immobilized mouse EPHA1-His at 10 μg/ml (100 μl/well) can bind mouse EFNA1-Fc ), The EC50 of mouse EFNA1-Fc is 21.3-49.8 ng/ml.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: EPHA1 (Ephrin Type A Receptor 1 (EPHA1))

Autre désignation: EphA1 (EPHA1 Produits)

Synonymes: EPH Protein, EPHT Protein, EPHT1 Protein, 5730453L17Rik Protein, AL033318 Protein, Eph Protein, Esk Protein, EPHA9 Protein, EPH receptor A1 Protein, Eph receptor A1 Protein, EPHA1 Protein, Epha1 Protein

Sujet:

Background: EPHA1 or EPH receptor A1 belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. An important role of Eph receptors and their ligands ephrins is to mediate cell-contact-dependent repulsion. Eph receptors and ephrins also act at boundaries to channel neuronal growth cones along specific pathways, restrict the migration of neural crest cells, and via bidirectional signaling prevent intermingling between hindbrain segments. Eph receptors and ephrins can also trigger an adhesive response of endothelial cells and are required for the remodeling of blood vessels. Eph receptors and ephrins have emerged as key regulators of the repulsion and adhesion of cells that underlie the establishment, maintainence, and remodeling of patterns of cellular organization. The ephrins and Eph receptors are implicated as positional labels that may guide the development of neural topographic maps.

Synonym: 5730453L17Rik,AL033318,Eph,Esk

Poids moléculaire: 58.6 kDa

UniProt: Q60750