FAM3B Protein (Fc Tag)

N° du produit ABIN7319765

Détail du produit

Antigène: FAM3B (Family with Sequence Similarity 3, Member B (FAM3B))

Type de proteíne: Recombinant

Origine: Humain

Source: Human Cells

Purification/Conjugué: Cette FAM3B protéine est marqué à la Fc Tag.

Fonction: Recombinant Human FAM3B (C-Fc)

Séquence: Glu30-Ser235

Attributs du produit: Recombinant Human Protein FAM3B is produced by our Mammalian expression system and the target gene encoding Glu30-Ser235 is expressed with a Fc tag at the C-terminus.

Pureté: >95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: FAM3B (Family with Sequence Similarity 3, Member B (FAM3B))

Autre désignation: FAM3B (FAM3B Produits)

Synonymes: 2-21 Protein, C21orf11 Protein, C21orf76 Protein, ORF9 Protein, PANDER Protein, 9030624C24Rik Protein, D16Jhu19e Protein, Pander Protein, RGD1311662 Protein, family with sequence similarity 3 member B Protein, family with sequence similarity 3, member B Protein, FAM3B Protein, Fam3b Protein

Classe de substances: Viral Protein

Sujet:

Background: FAM3B, also known as Pancreatic-derived factor (PANDER), is an islet-specific secreted cytokine specifically expressed at high levels in the islets of Langerhans of the endocrine pancreas. FAM3B can induce apoptosis of alpha and beta cells in a dose- and time-dependent manner. Previous studies showed that FAM3B regulates glucose and lipid metabolism through interaction with liver and endocrine pancreas. FAM3B silencing activates both extrinsic and intrinsic apoptotic pathways. In general, silencing FAM3B promoted p53 phosphorylation and induced p53 accumulation by decreasing Mdm2 expression, which resulted in apoptotic cell death.

Synonym: Sialic acid-binding Ig-like lectin 9,Siglec-9,CDw329,Protein FOAP-9,SIGLEC9

Poids moléculaire: 50 kDa

UniProt: P58499

Pathways: Hormone Transport