FCER2 Protein (His tag)

N° du produit ABIN7195673

Détail du produit

Antigène: FCER2 (Fc Fragment of IgE, Low Affinity II, Receptor For (CD23) (FCER2))

Type de proteíne: Recombinant

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette FCER2 protéine est marqué à la His tag.

Fonction: Recombinant Mouse CD23 Protein (His Tag)

Séquence: Glu 51-Pro 331

Attributs du produit: A DNA sequence encoding the extracellular domain of mouse FCER2A isoform A (P20693-1) (Glu 51-Pro 331) was fused with a polyhistidine tag at the N-terminus.

Pureté: > 92 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: FCER2 (Fc Fragment of IgE, Low Affinity II, Receptor For (CD23) (FCER2))

Autre désignation: CD23 (FCER2 Produits)

Synonymes: BLAST-2 Protein, CD23 Protein, CD23A Protein, CLEC4J Protein, FCE2 Protein, IGEBF Protein, Fcer2a Protein, Fc fragment of IgE receptor II Protein, FCER2 Protein, Fcer2 Protein

Sujet:

Background: Fc fragment of IgE, low affinity II, receptor for (CD23) or CD23 antigen is a member of the cluster of differentiation family. The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules present on white blood cells initially but found in almost any kind of cell of the body, providing targets for immunophenotyping of cells. Physiologically, CD molecules can act in numerous ways, often acting as receptors or ligands (the molecule that activates a receptor) important to the cell. A signal cascade is usually initiated, altering the behavior of the cell (see cell signaling). Some CD proteins do not play a role in cell signaling, but have other functions, such as cell adhesion. CD23/FCER2 is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Increased levels of soluble CD23/FCER2 cause the recruitment of non-sensitised B-cells in the presentation of antigen peptides to allergen-specific B-cells, therefore increasing the production of allergen specific IgE. IgE, in turn, is known to upregulate the cellular expression of CD23 and Fc epsilon RI (high-affinity IgE receptor).

Synonym: CD23,Fce2,Fcer2,Fcer2a,Ly-42

Poids moléculaire: 34.3 kDa

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process