FLRT2 Protein (His tag)

N° du produit ABIN7320057

Détail du produit

Antigène: FLRT2 (Fibronectin Leucine Rich Transmembrane Protein 2 (FLRT2))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette FLRT2 protéine est marqué à la His tag.

Fonction: Recombinant Mouse FLRT2 Protein (His Tag)(Active)

Séquence: Met1-Ser539

Attributs du produit: A DNA sequence encoding the mouse FLRT2 (Q8BLU0) (Met1-Ser539) was expressed with a C-terminal polyhistidine tag.

Pureté: > 95 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Measured by the ability of the immobilized protein to support the adhesion of Neuro-2A mouse neuroblastoma cells.When cells are added to coated plates(5μg/mL,100μL/well), approximately 50%-70% will adhere after 1 hour at 37°C.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: FLRT2 (Fibronectin Leucine Rich Transmembrane Protein 2 (FLRT2))

Autre désignation: FLRT2 (FLRT2 Produits)

Synonymes: fibronectin leucine rich transmembrane protein 2 S homeolog Protein, fibronectin leucine rich transmembrane protein 2 Protein, flrt2.S Protein, flrt2 Protein, FLRT2 Protein, Flrt2 Protein

Sujet:

Background: Fibronectin Leucine-Rich Transmembrane (FLRT) proteins are glycosylated membrane proteins expressed at the cell surface which localise in a homophilic manner to cell-cell contacts expressing the focal adhesion marker vinculin. FLRT1, FLRT2, and FLRT3, the three genes encode putative type I transmembrane proteins, each containing 10 leucine-rich repeats (LRR), a type III fibronectin (FN) domain, followed by the transmembrane region, and a short cytoplasmic tail. FLRT family members may function in cell adhesion and/or receptor signalling. Each member of the FLRT family has a distinct, highly regulated expression pattern, as was seen for the NLRR family. FLRT2 is expressed in a subset of the sclerotome, adjacent to the region that forms the syndetome, suggesting that interaction with FGF signalling may be a general property of FLRT proteins. All FLRTs can interact with FGFR1 and FLRTs can be induced by the activation of FGF signalling by FGF-2. FLRT proteins have a dual role, promoting FGF signalling and modulating homotypic cell adhesion. FLRT2 played critical roles in craniofacial development, and it was also present in the vomero-nasal organ, mandibular primodia, and the posterior aspects of the unfused and fused secondary palatal shelves.

Synonym: FLRT2

Poids moléculaire: 57.6 kDa

UniProt: Q8BLU0