GZMH Protein (His tag)

N° du produit ABIN7195990

Détail du produit

Antigène: GZMH (Granzyme H (Cathepsin G-Like 2, Protein H-CCPX) (GZMH))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette GZMH protéine est marqué à la His tag.

Fonction: Recombinant Human Granzyme H Protein (His Tag)

Séquence: Met 1-Leu 246

Attributs du produit: A DNA sequence encoding the human Granzyme H (NP_219491.1) (Met 1-Leu 246) with a C-terminal polyhistidine tag was expressed.

Pureté: > 90 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: GZMH (Granzyme H (Cathepsin G-Like 2, Protein H-CCPX) (GZMH))

Autre désignation: Granzyme H (GZMH Produits)

Synonymes: GZMH Protein, CCP-X Protein, CGL-2 Protein, CSP-C Protein, CTLA1 Protein, CTSGL2 Protein, granzyme H Protein, LOC617313 Protein, GZMH Protein

Sujet:

Background: Granzymes are key components of the immune response that play important roles in eliminating host cells infected by intracellular pathogens. Several granzymes are potent inducers of cell death. A total of eight granzymes (A-G and M) have been identified in the mouse, but only five are known in humans (A, B, H, M and granzyme 3), and granzyme H appears to be specifically human. Human granzyme H is a neutral serine protease that is expressed predominantly in the lymphokine-activated killer (LAK)/natural?killer (NK) compartment of the immune system. In adenovirus-infected cells in which granzyme B (gzmB) and downstream apoptosis pathways are inhibited, granzyme H directly cleaves the adenovirus DNA-binding protein (DBP), a viral component absolutely required for viral DNA replication. This virus demonstrated that gzmH directly induces an important decay in viral DNA replication. Interestingly, gzmH also cleaves the adenovirus 100K assembly protein, a major inhibitor of gzmB, and relieves gzmB inhibition. Granzyme H has a very high amino acid identity (>90%) with many portions of the granzyme B sequence, particularly near the amino terminus of the molecule despite performing a distinct enzymic function.

Synonym: CCP-X;CGL-2;CSP-C;CTLA1;CTSGL2;GZMH

Poids moléculaire: 26.7 kDa

NCBI Accession: NP_219491