GAP43 Protein (His tag)

N° du produit ABIN7195999

Détail du produit

Antigène: GAP43 (Growth Associated Protein 43 (GAP43))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette GAP43 protéine est marqué à la His tag.

Fonction: Recombinant Human GAP43/Neuromodulin Protein (His Tag)

Séquence: Met 1-Ala 238

Attributs du produit: A DNA sequence encoding the human GAP43 (P17677) (Met 1-Ala 238) was fused with a polyhistidine tag at the C-terminus.

Pureté: > 96 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: GAP43 (Growth Associated Protein 43 (GAP43))

Autre désignation: GAP43/Neuromodulin (GAP43 Produits)

Synonymes: B-50 Protein, PP46 Protein, Basp2 Protein, GAP-43 Protein, b-50 Protein, gap-43 Protein, gap43b Protein, pp46 Protein, cb310 Protein, gap Protein, gap43 Protein, gap43a Protein, growth associated protein 43 Protein, growth associated protein 43 L homeolog Protein, growth associated protein 43 S homeolog Protein, GAP43 Protein, Gap43 Protein, gap43.L Protein, gap43 Protein, gap43.S Protein

Sujet:

Background: Neuromodulin, also known as Axonal membrane protein GAP-43, Growth-associated protein 43, Neural phosphoprotein B-50, pp46 and GAP43, is a cell membrane protein which belongs to the neuromodulin family. Neuromodulin / GAP43 contains one IQ domain. Neuromodulin / GAP43 is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Neuromodulin / GAP43 is involved in neurite outgrowth, a crucial process for the differentiation of neurons. The sudden infant death syndrome (SIDS) is the main cause of postneonatal infant death and its cause is still unknown. Neuromodulin / GAP43 is a marker of synaptic plasticity and is critical for normal development of the serotonergic innervation. Neuromodulin / GAP43 is a major cortical cytoskeleton-associated and calmodulin binding protein that is widely and abundantly expressed during development, maintained in selected brain structures in the adult, and reinduced during nerve regeneration. CAP23 and GAP43 are functionally related intrinsic determinants of anatomical plasticity. These proteins function by locally promoting subplasmalemmal actin cytoskeleton accumulation.

Synonym: B-50;PP46

Poids moléculaire: 26.2 kDa

UniProt: P17677