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GNB2L1 Protein (His tag,MBP tag)

GNB2L1 Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant > 83 % as determined by reducing SDS-PAGE.
N° du produit ABIN7317368
  • Antigène Voir toutes GNB2L1 Protéines
    GNB2L1 (Guanine Nucleotide Binding Protein (G Protein), beta Polypeptide 2-Like 1 (GNB2L1))
    Type de proteíne
    Recombinant
    Origine
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Source
    • 9
    • 3
    • 2
    • 2
    • 1
    • 1
    Escherichia coli (E. coli)
    Purification/Conjugué
    Cette GNB2L1 protéine est marqué à la His tag,MBP tag.
    Fonction
    Recombinant Human RACK1/GNB2L1 Protein (His & MBP Tag)
    Séquence
    Met 1-Arg 317
    Attributs du produit
    A DNA sequence encoding the human GNB2L1 (P63244) (Met 1-Arg 317) was fused with an N-terminal polyhistidine-tagged MBP tag at the N-terminus.
    Pureté
    > 83 % as determined by reducing SDS-PAGE.
    Top Product
    Discover our top product GNB2L1 Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile PBS, pH 7.5
    Stock
    4 °C,-20 °C,-80 °C
    Stockage commentaire
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Antigène
    GNB2L1 (Guanine Nucleotide Binding Protein (G Protein), beta Polypeptide 2-Like 1 (GNB2L1))
    Autre désignation
    RACK1/GNB2L1 (GNB2L1 Produits)
    Synonymes
    MGC53289 Protein, GNB2L1 Protein, AL033335 Protein, GB-like Protein, Gnb2-rs1 Protein, Rack1 Protein, p205 Protein, RACK1 Protein, H12.3 Protein, HLC-7 Protein, PIG21 Protein, rack1 Protein, wu:fb80d08 Protein, wu:fk65d12 Protein, gnb2-rs1 Protein, h12.3 Protein, hlc-7 Protein, pig21 Protein, C12-3 Protein, c12.3 Protein, guanine nucleotide binding protein, beta 2, related sequence 1 Protein, receptor for activated C kinase 1 Protein, guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 Protein, receptor for activated C kinase 1 L homeolog Protein, Guanine nucleotide-binding protein subunit beta-2-like 1 Protein, gnb2l1 Protein, RACK1 Protein, Rack1 Protein, rack1.L Protein, rack-1 Protein
    Sujet

    Background: Calmodulin-like protein 3 (CALML3) is similar to that of authentic calmodulin and may actually compete with calmodulin by binding, with different affinity, to cellular substrates. Calmodulin-like protein 3 (CALML3) is a tumor-sensitive protein specifically expressed in normal epithelial cells but downregulated in tumorigenesis. Downregulation of the protein is an early event in breast cancer development. One of the most pressing questions raised by the discovery of CLP/CALML3 is that of its potential targets. Although it is 85 % identical to human calmodulin, the distinct properties of CLP suggest that it has specific targets or targets that only partially overlap with those of calmodulin. Research has identified the unconventional myosin-10 (Myo10) as a specific target of CALML3. The discovery of Myo10 as a specific target of CALML3 is highly significant and suggests multiple lines of further research such as investigations of the Ca2+ regulation of Myo10 and the role of the loss of CLP in epithelial differentiation, adhesion, and cancer. Cells expressing CALML3 displayed a striking increase in the number and length of myosin-10-positive filopodia and showed increased mobility in a wound healing assay.

    Synonym: Gnb2-rs1,H12.3,HLC-7,PIG21,RACK1

    Poids moléculaire
    78.7 kDa
    UniProt
    P63244
    Pathways
    cAMP Metabolic Process, Positive Regulation of Endopeptidase Activity
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