GBP1 Protein (His tag)

N° du produit ABIN7317360

Détail du produit

Antigène: GBP1 (Guanylate Binding Protein 1, Interferon-Inducible (GBP1))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette GBP1 protéine est marqué à la His tag.

Fonction: Recombinant Human GBP1 Protein (His Tag)

Séquence: Met 1-Cys 589

Attributs du produit: A DNA sequence encoding the human GBP1 (AAA35871.1) (Met 1-Cys 589) was fused with a polyhistidine tag at the C-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: GBP1 (Guanylate Binding Protein 1, Interferon-Inducible (GBP1))

Autre désignation: GBP1 (GBP1 Produits)

Synonymes: guanylate binding protein 1 Protein, guanylate binding protein 1, interferon-inducible Protein, guanylate binding protein 1, interferon-inducible, 67kD Protein, GBP1 Protein, Gbp1 Protein, gbp1 Protein

Sujet:

Background: Guanylate-binding protein 1 (GBP-1) is a member of the GBP family whose members are GTPases induced in response to interferon-λ (IFN-λ), with seven highly homologous members in humans, termed HuGBP-1 to HuGBP-7. GBP-1 expression is induced by type1 and type2 interferons, including IFN-λ and also by interleukin-1β (IL-1β), IL-1α, and tumor necrosis factor-α (TNF-α). GBP-1 is key to the protective immunity against microbial and viral pathogens. GBP-1 was only secreted from endothelial cells. Secretion occurred without the presence of a leader peptide. Secretion procession is a nonclassical, likely ABC transporter-dependent, pathway and independent of GBP-1 GTPase activity and isoprenylation, and did not require additional interferon-λ-induced factors. Clinically most important was the detection of significantly increased GBP-1 concentrations in the cerebrospinal fluid of patients with bacterial meningitis as compared to control patients.

Synonym: GBP1

Poids moléculaire: 69 kDa

Pathways: Cellular Response to Molecule of Bacterial Origin