Haptoglobin Protein (HP) (AA 19-160, AA 162-406) (His tag)

N° du produit ABIN7318556

Détail du produit

Antigène: Haptoglobin (HP)

Type de proteíne: Recombinant

Attributs du protein: AA 162-406, AA 19-160

Origine: Humain

Source: Human Cells

Purification/Conjugué: Cette Haptoglobin protéine est marqué à la His tag.

Fonction: Recombinant Human Haptoglobin/Zonulin Protein (aa 19-160&aa 162-406, His Tag)

Séquence: Val19-Gln160&Ile162-Asn406

Attributs du produit: Recombinant Human Haptoglobin/Zonulin is produced by our Mammalian expression system and the target gene encoding Val19-Gln160(alpha chain)&Ile162-Asn406(beta chain) is expressed with a 6His tag at the C-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, 1 mM DTT, pH 7.4.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: Haptoglobin (HP)

Autre désignation: Haptoglobin/Zonulin (HP Produits)

Synonymes: HP Protein, wu:fb64e01 Protein, BP Protein, HP2ALPHA2 Protein, HPA1S Protein, HP-1 Protein, HPR Protein, Zonulin Protein, haptoglobin Protein, haptoglobin-like Protein, HP Protein, hp Protein, Hp Protein, LOC479668 Protein, LOC101102413 Protein

Sujet:

Background: Haptoglobin(HP) is a secreted protein which is a member of the peptidase S1 family of serine proteases. As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial, Antioxidant has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.

Synonym: Haptoglobin,Zonulin,HP

Poids moléculaire: 15.9&28.3

UniProt: P00738

Pathways: Transition Metal Ion Homeostasis