HSPD1 Protein (GST tag,His tag)

N° du produit ABIN7317578

Détail du produit

Antigène: HSPD1 (Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette HSPD1 protéine est marqué à la GST tag,His tag.

Fonction: Recombinant Human HSPD1/HSP60 Protein (His & GST Tag)

Séquence: Leu 2-Phe 573

Attributs du produit: A DNA sequence encoding the human HSP60 (NP_955472.1) (Leu 2-Phe 573) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Pureté: > 90 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: HSPD1 (Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1))

Autre désignation: HSPD1/HSP60 (HSPD1 Produits)

Synonymes: CPN60 Protein, GROEL Protein, HLD4 Protein, HSP-60 Protein, HSP60 Protein, HSP65 Protein, HuCHA60 Protein, SPG13 Protein, chaperonin Protein, cpn60 Protein, groel Protein, hld4 Protein, hsp60 Protein, hsp65 Protein, spg13 Protein, 60kDa Protein, Hsp60 Protein, 12 Protein, BP5 Protein, CG12101 Protein, Cpn60 Protein, Dmel\\CG12101 Protein, Dmhsp60 Protein, G62 Protein, HSP60A Protein, Hsp60A Protein, IEF16 Protein, Mmp-P1 Protein, SSP 7506 Protein, d-hsp60 Protein, hsp60A Protein, l(1)10Ac Protein, l(1)BP5 Protein, l(1)G8 Protein, l(1)HM21 Protein, l(1)L12 Protein, l(1)dp025 Protein, cb863 Protein, fa04a05 Protein, fb22d10 Protein, fi27b05 Protein, id:ibd2197 Protein, sb:cb144 Protein, wu:fa04a05 Protein, wu:fb22d10 Protein, wu:fi04a12 Protein, wu:fi27b05 Protein, MIF4 Protein, MNA2 Protein, mopA Protein, groL Protein, crpA Protein, Hspd1-30p Protein, heat shock protein family D (Hsp60) member 1 Protein, heat shock protein family D (Hsp60) member 1 S homeolog Protein, 60 kDa heat shock protein, mitochondrial Protein, heat shock protein 1 (chaperonin) Protein, Heat shock protein 60A Protein, heat shock 60 protein 1 Protein, chaperone ATPase HSP60 Protein, molecular chaperone GroEL Protein, thermosome subunit Protein, chaperonin GroEL Protein, mitochondrial chaperonin Protein, heat shock protein family D member 1 Protein, HSPD1 Protein, hspd1.S Protein, hspd1 Protein, LOC100414401 Protein, Hspd1 Protein, Hsp60A Protein, HSP60 Protein, groEL Protein, MMP_RS07785 Protein, groEl Protein, LOC100136430 Protein

Sujet:

Background: HSPD1, also known as HSP60, is a member of the chaperonin family. HSPD1 may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. It may also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. HSPD1 gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13.Defects in HSPD1 are a cause of spastic paraplegia autosomal dominant type 13 (SPG13). Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Defects in HSPD1 are the cause of leukodystrophy hypomyelinating type 4 (HLD4); also called mitochondrial HSP60 chaperonopathy or MitCHAP-60 disease. HLD4 is a severe autosomal recessive hypomyelinating leukodystrophy. HSPD1 is cinically characterized by infantile-onset rotary nystagmus, progressive spastic paraplegia, neurologic regression, motor impairment, profound mental retardation. Death usually occurrs within the first two decades of life.Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Synonym: CPN60;GROEL;HLD4;HSP-60;HSP60;HSP65;HuCHA60;SPG13

Poids moléculaire: 88.7 kDa

NCBI Accession: NP_955472

Pathways: Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity