HFE2 Protein (His tag)

N° du produit ABIN7317877

Détail du produit

Antigène: HFE2 (Hemochromatosis Type 2 (Juvenile) (HFE2))

Type de proteíne: Recombinant

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette HFE2 protéine est marqué à la His tag.

Fonction: Recombinant Human Hemojuvelin/HFE2 Protein (His Tag)

Séquence: Met 1-Ser 399

Attributs du produit: A DNA sequence encoding the mature form of human HFE2 isoform a (Q6ZVN8-1) (Met 1-Ser 399) was fused with a polyhistidine tag at the C-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, 500 mM NaCl, pH 7.0, 10 % gly

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: HFE2 (Hemochromatosis Type 2 (Juvenile) (HFE2))

Autre désignation: Hemojuvelin/HFE2 (HFE2 Produits)

Synonymes: HFE2A Protein, HJV Protein, JH Protein, RGMC Protein, HFE2 Protein, DKFZp468F2322 Protein, 2310035L15Rik Protein, 5230400G09Rik Protein, AI414844 Protein, AI789733 Protein, DL-M Protein, Rgmc Protein, hemojuvelin Protein, RGMr Protein, hjv Protein, id:ibd3464 Protein, wu:fb38f10 Protein, zgc:136698 Protein, hemochromatosis type 2 (juvenile) Protein, hemochromatosis type 2 Protein, HFE2 Protein, Hfe2 Protein, hfe2 Protein

Sujet:

Background: Hemojuvelin, also known as HFE2, is a membrane-bound and soluble protein which belongs to the repulsive guidance molecule (RGM) family. It is known that RGMs function through Neogenin, a homologue of the Netrin receptor deleted in colon cancer. In mammals, RGM family consists of three glycoproteins which have discrete expression patterns and functions (RGM-A, RGM-B, and RGM-C). Hemojuvelin is expressed in adult and fetal liver, heart, and skeletal muscle. Hemojuvelin acts as a bone morphogenetic protein (BMP) coreceptor. Enhancement of BMP signaling regulates hepcidin (HAMP) expression and iron metabolism. It plays a key role in iron metabolism. Hemojuvelin represents the cellular receptor for hepcidin. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. Defects in hemojuvelin are the cause of hemochromatosis type 2A, also known as juvenile hemochromatosis (JH).

Synonym: HFE2A,HJV,JH,RGMC

Poids moléculaire: 40 kDa

Pathways: Transition Metal Ion Homeostasis