HDAC8 Protein (His tag)

N° du produit ABIN7320338

Détail du produit

Antigène: HDAC8 (Histone Deacetylase 8 (HDAC8))

Type de proteíne: Recombinant

Origine: Souris

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette HDAC8 protéine est marqué à la His tag.

Fonction: Recombinant Mouse HDAC8/HDACL1 Protein (His Tag)

Séquence: Met 1-Val 377

Attributs du produit: A DNA sequence encoding the mouse HDAC8 isoform 1 (Q8VH37-1) (Met 1-Val 377) was expressed,with a C-terminal polyhistidine tag.

Pureté: > 90 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: HDAC8 (Histone Deacetylase 8 (HDAC8))

Autre désignation: HDAC8/HDACL1 (HDAC8 Produits)

Synonymes: HD8 Protein, CDLS5 Protein, HDACL1 Protein, MRXS6 Protein, RPD3 Protein, WTS Protein, 2610007D20Rik Protein, RGD1562895 Protein, wu:fd19a02 Protein, zgc:66196 Protein, ATHDA8 Protein, HDA8 Protein, HISTONE DEACETYLASE 8 Protein, T27G7.14 Protein, T27G7_14 Protein, histone deacetylase 8 Protein, histone deacetylase 8 Protein, histone deacetylase 8 L homeolog Protein, CC1G_05302 Protein, hdac8 Protein, HDAC8 Protein, Hdac8 Protein, hdac8.L Protein, HDA08 Protein

Sujet:

Background: Histone deacetylase 8, also known as HDAC8 and HDACL1, is a nucleus and cytoplasm protein which belongs to the histone deacetylase family and HD type 1 subfamily. Histone deacetylases (HDACs) are a growing family of enzymes implicated in transcriptional regulation by affecting the acetylation state of core histones in the nucleus of cells. HDAC8 / HDACL1 is weakly expressed in most tissues. It expressed at higher level in heart, brain, kidney and pancreas and also in liver, lung, placenta, prostate and kidney. HDAC8 / HDACL1 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones ( H2A, H2B, H3 and H4 ). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDAC8 / HDACL1 may play a role in smooth muscle cell contractility. HDAC8 / HDACL1 may be a potential drug target for neuroblastoma differentiation therapy using selective inhibitors, avoiding unspecific side effects.

Synonym: 2610007D20Rik

Poids moléculaire: 43.1 kDa

Pathways: Cellular Glucan Metabolic Process