IGFBP2 Protein (Fc Tag)

N° du produit ABIN7196214

Détail du produit

Antigène: IGFBP2 (Insulin-Like Growth Factor Binding Protein 2, 36kDa (IGFBP2))

Type de proteíne: Recombinant

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette IGFBP2 protéine est marqué à la Fc Tag.

Fonction: Recombinant Mouse IGFBP-2/IGFBP2 Protein (Fc Tag)

Séquence: Met1-Gln305

Attributs du produit: A DNA sequence encoding the mouse Igfbp2 (NP_032368.2) (Met1-Gln305) was expressed with the Fc region of human IgG1 at the C-terminus.

Pureté: > (65.9+24.5) % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: IGFBP2 (Insulin-Like Growth Factor Binding Protein 2, 36kDa (IGFBP2))

Autre désignation: IGFBP-2/IGFBP2 (IGFBP2 Produits)

Synonymes: IBP2 Protein, IGF-BP53 Protein, AI255832 Protein, IBP-2 Protein, Igfbp-2 Protein, mIGFBP-2 Protein, IGFBP-2 Protein, ILGFBPA Protein, pIGFBP-2 Protein, igfbp2 Protein, MGC65741 Protein, MGC76823 Protein, MGC174445 Protein, IGFBP2 Protein, ibp2 Protein, igf-bp53 Protein, igfbp2a Protein, si:ch211-2k18.3 Protein, insulin like growth factor binding protein 2 Protein, insulin-like growth factor binding protein 2 Protein, insulin-like growth factor binding protein 2a Protein, insulin-like growth factor binding protein 2b Protein, IGFBP2 Protein, Igfbp2 Protein, igfbp2a Protein, igfbp2 Protein, igfbp2b Protein

Sujet:

Background: IGFBP-2, also known as IGFBP2, is a insulin-like growth factor-binding protein (IGFBP). IGFBPs prolong the half-life of the IGFs , control bioavailability, activity, and distribution of insulin-like growth factor (IGF) through high-affinity IGFBP/IGF complexes. Six high-affinity IGF-binding proteins (IGFBP-1 to -6) have been identified. The six IGFBPs are structurally related but encoded by distinct genes. IGFBPs have a high affinity for IGFs. Some members of the IGFBP family have been consistently shown to inhibit IGF actions by preventing them from gaining access to the IGF receptors, while others potentiate IGF actions by facilitating the ligand-receptor interaction. IGFBP-2 is overexpressed in many malignancies and is often correlated with an increasingly malignant status of the tumor, pointing to a potential involvement of IGFBP-2 in tumorigenesis. It contains 1 IGFBP N-terminal domain and 1 thyroglobulin type-1 domain. It inhibits IGF-mediated growth and developmental rates.

Synonym: AI255832,IBP-2,Igfbp-2,mIGFBP-2

Poids moléculaire: 56.6 kDa

NCBI Accession: NP_032368

Pathways: Myometrial Relaxation and Contraction, Growth Factor Binding, Activated T Cell Proliferation